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Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation
Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex differences in whole-body physiology. We find that carbohydrate handlin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700282/ https://www.ncbi.nlm.nih.gov/pubmed/31398343 http://dx.doi.org/10.1016/j.cell.2019.07.029 |
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author | Hudry, Bruno de Goeij, Eva Mineo, Alessandro Gaspar, Pedro Hadjieconomou, Dafni Studd, Chris Mokochinski, Joao B. Kramer, Holger B. Plaçais, Pierre-Yves Preat, Thomas Miguel-Aliaga, Irene |
author_facet | Hudry, Bruno de Goeij, Eva Mineo, Alessandro Gaspar, Pedro Hadjieconomou, Dafni Studd, Chris Mokochinski, Joao B. Kramer, Holger B. Plaçais, Pierre-Yves Preat, Thomas Miguel-Aliaga, Irene |
author_sort | Hudry, Bruno |
collection | PubMed |
description | Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex differences in whole-body physiology. We find that carbohydrate handling is male-biased in a specific portion of the intestine. In contrast to known sexual dimorphisms in invertebrates, the sex differences in intestinal carbohydrate metabolism are extrinsically controlled by the adjacent male gonad, which activates JAK-STAT signaling in enterocytes within this intestinal portion. Sex reversal experiments establish roles for this male-biased intestinal metabolic state in controlling food intake and sperm production through gut-derived citrate. Our work uncovers a male gonad-gut axis coupling diet and sperm production, revealing that metabolic communication across organs is physiologically important. The instructive role of citrate in inter-organ communication might be significant in more biological contexts than previously recognized. |
format | Online Article Text |
id | pubmed-6700282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-67002822019-08-22 Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation Hudry, Bruno de Goeij, Eva Mineo, Alessandro Gaspar, Pedro Hadjieconomou, Dafni Studd, Chris Mokochinski, Joao B. Kramer, Holger B. Plaçais, Pierre-Yves Preat, Thomas Miguel-Aliaga, Irene Cell Article Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to investigate how gut-derived signals contribute to sex differences in whole-body physiology. We find that carbohydrate handling is male-biased in a specific portion of the intestine. In contrast to known sexual dimorphisms in invertebrates, the sex differences in intestinal carbohydrate metabolism are extrinsically controlled by the adjacent male gonad, which activates JAK-STAT signaling in enterocytes within this intestinal portion. Sex reversal experiments establish roles for this male-biased intestinal metabolic state in controlling food intake and sperm production through gut-derived citrate. Our work uncovers a male gonad-gut axis coupling diet and sperm production, revealing that metabolic communication across organs is physiologically important. The instructive role of citrate in inter-organ communication might be significant in more biological contexts than previously recognized. Cell Press 2019-08-08 /pmc/articles/PMC6700282/ /pubmed/31398343 http://dx.doi.org/10.1016/j.cell.2019.07.029 Text en © 2019 Medical Research Council on behalf of UKRI and Imperial College London http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hudry, Bruno de Goeij, Eva Mineo, Alessandro Gaspar, Pedro Hadjieconomou, Dafni Studd, Chris Mokochinski, Joao B. Kramer, Holger B. Plaçais, Pierre-Yves Preat, Thomas Miguel-Aliaga, Irene Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title_full | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title_fullStr | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title_full_unstemmed | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title_short | Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation |
title_sort | sex differences in intestinal carbohydrate metabolism promote food intake and sperm maturation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700282/ https://www.ncbi.nlm.nih.gov/pubmed/31398343 http://dx.doi.org/10.1016/j.cell.2019.07.029 |
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