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SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

Sirtuin 5 (SIRT5), a mitochondrial class III NAD-dependent deacetylase, plays controversial roles in tumorigenesis and chemoresistance. Accordingly, its role in ovarian cancer development and drug resistance is not fully understood. Here, we demonstrate that SIRT5 is increased in ovarian cancer tiss...

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Detalles Bibliográficos
Autores principales:	Sun, Xiaodan, Wang, Shouhan, Gai, Junda, Guan, Jingqian, Li, Ji, Li, Yizhuo, Zhao, Jinming, Zhao, Chen, Fu, Lin, Li, Qingchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700301/ https://www.ncbi.nlm.nih.gov/pubmed/31456942 http://dx.doi.org/10.3389/fonc.2019.00754

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