Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregna...

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Detalles Bibliográficos
Autores principales: Russell, Mark W., Moldenhauer, Julie S., Rychik, Jack, Burnham, Nancy B., Zullo, Erin, Parry, Samuel I., Simmons, Rebecca A., Elovitz, Michal A., Nicolson, Susan C., Linn, Rebecca L., Johnson, Mark P., Yu, Sunkyung, Sampson, Matthew G., Hakonarson, Hakon, Gaynor, J. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700409/
https://www.ncbi.nlm.nih.gov/pubmed/31453292
http://dx.doi.org/10.1016/j.dib.2019.104311
Descripción
Sumario:The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019).

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