Cargando…

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer

Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo synthesis of purines, and certain amino acids...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eich, Marie-Lisa, Rodriguez Pena, Maria Del Carmen, Chandrashekar, Darshan Shimoga, Chaux, Alcides, Agarwal, Sumit, Gordetsky, Jennifer B., Ferguson, James E., Sonpavde, Guru P., Netto, George J., Varambally, Sooryanarayana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2019
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700437/ https://www.ncbi.nlm.nih.gov/pubmed/31401334 http://dx.doi.org/10.1016/j.tranon.2019.07.012

Ejemplares similares

A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression()
por: Chakravarthi, Balabhadrapatruni V.S.K., et al.
Publicado: (2018)

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
por: Zhao, Li Na, et al.
Publicado: (2022)

MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer()()
por: Agarwal, Sumit, et al.
Publicado: (2019)

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)
por: Lee, Lung-Chun, et al.
Publicado: (2021)

ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors
por: Rehman, Hasibur, et al.
Publicado: (2022)

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
por: Shin, Minhye, et al.
Publicado: (2017)

Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma
por: Shi, Lu-feng, et al.
Publicado: (2021)

Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma
por: Robinson, Alyncia D., et al.
Publicado: (2021)

Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study
por: Neagos, D, et al.
Publicado: (2010)

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance
por: He, Huan, et al.
Publicado: (2020)

Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells
por: Chandrashekar, Darshan S., et al.
Publicado: (2021)

Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis
por: He, Donglin, et al.
Publicado: (2018)

Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women
por: Saleh, Mansoor, et al.
Publicado: (2021)

DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
por: Agarwal, Sumit, et al.
Publicado: (2022)

Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer
por: Chandrashekar, Darshan Shimoga, et al.
Publicado: (2020)

Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers
por: Chen, Fengju, et al.
Publicado: (2019)

miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia
por: Gu, Yueli, et al.
Publicado: (2017)

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach
por: Rana, Nisarg, et al.
Publicado: (2023)

UALCAN: An update to the integrated cancer data analysis platform
por: Chandrashekar, Darshan Shimoga, et al.
Publicado: (2022)

Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
por: Zhang, Yiqun, et al.
Publicado: (2022)

Author Correction: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
por: Zhang, Yiqun, et al.
Publicado: (2022)

Global impact of somatic structural variation on the cancer proteome
por: Chen, Fengju, et al.
Publicado: (2023)

Global molecular alterations involving recurrence or progression of pediatric brain tumors
por: Chen, Fengju, et al.
Publicado: (2021)

Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis
por: Zhang, Hongtuan, et al.
Publicado: (2013)

Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease
por: Liu, Hanjun, et al.
Publicado: (2023)

Prostate Cancer Imaging and Biomarkers Guiding Safe Selection of Active Surveillance
por: Glaser, Zachary A., et al.
Publicado: (2017)

MTHFD1 controls DNA methylation in Arabidopsis
por: Groth, Martin, et al.
Publicado: (2016)

Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers
por: Kaur, Jaspreet, et al.
Publicado: (2022)

GREAM: A Web Server to Short-List Potentially Important Genomic Repeat Elements Based on Over-/Under-Representation in Specific Chromosomal Locations, Such as the Gene Neighborhoods, within or across 17 Mammalian Species
por: Chandrashekar, Darshan Shimoga, et al.
Publicado: (2015)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
por: Asai, Ayumu, et al.
Publicado: (2018)

Crystal structure of Thermus thermophilus methylenetetrahydrofolate dehydrogenase and determinants of thermostability
por: Maiello, Fernando, et al.
Publicado: (2020)

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer
por: Hanna, Ann, et al.
Publicado: (2018)

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses()
por: Chandrashekar, Darshan S., et al.
Publicado: (2017)

Whole-Exome Sequencing Reveals High Mutational Concordance between Primary and Matched Recurrent Triple-Negative Breast Cancers
por: Kaur, Jaspreet, et al.
Publicado: (2023)

Circulating Biomarkers in Bladder Cancer
por: Nandagopal, Lakshminarayanan, et al.
Publicado: (2016)

Triglyceride regulate ACE2 level through MTHFD1
por: Ma, Xiaohua, et al.
Publicado: (2021)

PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer
por: Agarwal, Sumit, et al.
Publicado: (2020)

TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status
por: Agarwal, Sumit, et al.
Publicado: (2020)

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L)
por: Leow, Melvin Khee-Shing, et al.
Publicado: (2022)

MTHFD2- a new twist?
por: Tedeschi, Philip M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_trkirv71ht1dd17i9eilhehalq