Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells

Pyruvate is a key metabolite in glycolysis and the tricarboxylic acid (TCA) cycle. Exogenous pyruvate modulates metabolism, provides cellular protection, and is essential for the maintenance of human preimplantation embryos and human embryonic stem cells (hESCs). However, little is known about how p...

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Detalles Bibliográficos
Autores principales: Song, Chengcheng, Xu, Faxiang, Ren, Zhili, Zhang, Yumeng, Meng, Ya, Yang, Yiqi, Lingadahalli, Shreyas, Cheung, Edwin, Li, Gang, Liu, Weiwei, Wan, Jianbo, Zhao, Yang, Chen, Guokai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700476/
https://www.ncbi.nlm.nih.gov/pubmed/31353224
http://dx.doi.org/10.1016/j.stemcr.2019.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700476/
https://www.ncbi.nlm.nih.gov/pubmed/31353224
http://dx.doi.org/10.1016/j.stemcr.2019.06.003

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