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Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700572/ https://www.ncbi.nlm.nih.gov/pubmed/31401577 http://dx.doi.org/10.1136/bcr-2019-230366 |
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author | McLucas, Bruce Vail, Eric Chua, Katherine Jane Walt, Gabriel |
author_facet | McLucas, Bruce Vail, Eric Chua, Katherine Jane Walt, Gabriel |
author_sort | McLucas, Bruce |
collection | PubMed |
description | Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old woman (Gravida 2, Para 2) received Gardasil in 2006. Subsequently, her pap smear revealed low grade squamous intraepithelial lesion. Cervical biopsies performed in 2015 and 2016 revealed cervical intraepithelial neoplasia grade 1 (CIN 1). She underwent loop electrosurgical excision procedure for persistent CIN 1, which demonstrated CIN 3. Genotyping revealed HPV type 56 infection. The advancement of Gardasil-9 vaccine only offers 90% protection to patients against HPV-related disease. Lay literature may mislead patients to think they have no risk of HPV infection. |
format | Online Article Text |
id | pubmed-6700572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67005722019-08-29 Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination McLucas, Bruce Vail, Eric Chua, Katherine Jane Walt, Gabriel BMJ Case Rep Reminder of Important Clinical Lesson Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old woman (Gravida 2, Para 2) received Gardasil in 2006. Subsequently, her pap smear revealed low grade squamous intraepithelial lesion. Cervical biopsies performed in 2015 and 2016 revealed cervical intraepithelial neoplasia grade 1 (CIN 1). She underwent loop electrosurgical excision procedure for persistent CIN 1, which demonstrated CIN 3. Genotyping revealed HPV type 56 infection. The advancement of Gardasil-9 vaccine only offers 90% protection to patients against HPV-related disease. Lay literature may mislead patients to think they have no risk of HPV infection. BMJ Publishing Group 2019-08-10 /pmc/articles/PMC6700572/ /pubmed/31401577 http://dx.doi.org/10.1136/bcr-2019-230366 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Reminder of Important Clinical Lesson McLucas, Bruce Vail, Eric Chua, Katherine Jane Walt, Gabriel Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title | Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title_full | Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title_fullStr | Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title_full_unstemmed | Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title_short | Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination |
title_sort | cervical intraepithelial neoplasia grade 3 in a patient following gardasil vaccination |
topic | Reminder of Important Clinical Lesson |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700572/ https://www.ncbi.nlm.nih.gov/pubmed/31401577 http://dx.doi.org/10.1136/bcr-2019-230366 |
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