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Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination

Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old...

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Autores principales: McLucas, Bruce, Vail, Eric, Chua, Katherine Jane, Walt, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700572/
https://www.ncbi.nlm.nih.gov/pubmed/31401577
http://dx.doi.org/10.1136/bcr-2019-230366
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author McLucas, Bruce
Vail, Eric
Chua, Katherine Jane
Walt, Gabriel
author_facet McLucas, Bruce
Vail, Eric
Chua, Katherine Jane
Walt, Gabriel
author_sort McLucas, Bruce
collection PubMed
description Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old woman (Gravida 2, Para 2) received Gardasil in 2006. Subsequently, her pap smear revealed low grade squamous intraepithelial lesion. Cervical biopsies performed in 2015 and 2016 revealed cervical intraepithelial neoplasia grade 1 (CIN 1). She underwent loop electrosurgical excision procedure for persistent CIN 1, which demonstrated CIN 3. Genotyping revealed HPV type 56 infection. The advancement of Gardasil-9 vaccine only offers 90% protection to patients against HPV-related disease. Lay literature may mislead patients to think they have no risk of HPV infection.
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spelling pubmed-67005722019-08-29 Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination McLucas, Bruce Vail, Eric Chua, Katherine Jane Walt, Gabriel BMJ Case Rep Reminder of Important Clinical Lesson Essentially all cervical dysplasia is caused by human papilloma virus (HPV). Three HPV vaccines have been available, with Gardasil-9 being the most recently approved in the USA. Gardasil-9 covers high-risk HPV strains 16, 18, 31, 33, 45, 52 and 58 as well as low-risk strains 6 and 11. A 33-year-old woman (Gravida 2, Para 2) received Gardasil in 2006. Subsequently, her pap smear revealed low grade squamous intraepithelial lesion. Cervical biopsies performed in 2015 and 2016 revealed cervical intraepithelial neoplasia grade 1 (CIN 1). She underwent loop electrosurgical excision procedure for persistent CIN 1, which demonstrated CIN 3. Genotyping revealed HPV type 56 infection. The advancement of Gardasil-9 vaccine only offers 90% protection to patients against HPV-related disease. Lay literature may mislead patients to think they have no risk of HPV infection. BMJ Publishing Group 2019-08-10 /pmc/articles/PMC6700572/ /pubmed/31401577 http://dx.doi.org/10.1136/bcr-2019-230366 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Reminder of Important Clinical Lesson
McLucas, Bruce
Vail, Eric
Chua, Katherine Jane
Walt, Gabriel
Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title_full Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title_fullStr Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title_full_unstemmed Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title_short Cervical intraepithelial neoplasia grade 3 in a patient following Gardasil vaccination
title_sort cervical intraepithelial neoplasia grade 3 in a patient following gardasil vaccination
topic Reminder of Important Clinical Lesson
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700572/
https://www.ncbi.nlm.nih.gov/pubmed/31401577
http://dx.doi.org/10.1136/bcr-2019-230366
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