CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners

Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long-term hematopoietic homeostasis during stress and aging. Y...

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Detalles Bibliográficos
Autores principales: He, Liang, Beghi, Florian, Baral, Viviane, Dépond, Mallorie, Zhang, Yanyan, Joulin, Virginie, Rueda, Bo R., Gonin, Patrick, Foudi, Adlen, Wittner, Monika, Louache, Fawzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700604/
https://www.ncbi.nlm.nih.gov/pubmed/31327733
http://dx.doi.org/10.1016/j.stemcr.2019.06.002

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