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Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700705/ https://www.ncbi.nlm.nih.gov/pubmed/31435165 http://dx.doi.org/10.3748/wjg.v25.i30.4074 |
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author | Yeh, Matthew M Bosch, Dustin E Daoud, Sayed S |
author_facet | Yeh, Matthew M Bosch, Dustin E Daoud, Sayed S |
author_sort | Yeh, Matthew M |
collection | PubMed |
description | Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α expression has been associated with many human diseases such as ulcerative colitis, colon cancer, maturity-onset diabetes of the young, liver cirrhosis, and hepatocellular carcinoma. However, the precise role of HNF4α in the etiology of these human pathogenesis is not well understood. Limited information is known about the role of HNF4α isoforms in liver and gastrointestinal disease progression. There is, therefore, a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes. In this review, we will update our current understanding on the role of HNF4α in human liver and gastrointestinal diseases. We further provide additional information on possible use of HNF4α as a target for potential therapeutic approaches. |
format | Online Article Text |
id | pubmed-6700705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-67007052019-08-21 Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases Yeh, Matthew M Bosch, Dustin E Daoud, Sayed S World J Gastroenterol Review Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α expression has been associated with many human diseases such as ulcerative colitis, colon cancer, maturity-onset diabetes of the young, liver cirrhosis, and hepatocellular carcinoma. However, the precise role of HNF4α in the etiology of these human pathogenesis is not well understood. Limited information is known about the role of HNF4α isoforms in liver and gastrointestinal disease progression. There is, therefore, a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes. In this review, we will update our current understanding on the role of HNF4α in human liver and gastrointestinal diseases. We further provide additional information on possible use of HNF4α as a target for potential therapeutic approaches. Baishideng Publishing Group Inc 2019-08-14 2019-08-14 /pmc/articles/PMC6700705/ /pubmed/31435165 http://dx.doi.org/10.3748/wjg.v25.i30.4074 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Yeh, Matthew M Bosch, Dustin E Daoud, Sayed S Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title_full | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title_fullStr | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title_full_unstemmed | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title_short | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
title_sort | role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700705/ https://www.ncbi.nlm.nih.gov/pubmed/31435165 http://dx.doi.org/10.3748/wjg.v25.i30.4074 |
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