Cargando…

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

Ischemic injury to white matter tracts is increasingly recognized to play a key role in age-related cognitive decline, vascular dementia, and Alzheimer’s disease. Knowledge of the effects of ischemic axonal injury on cortical neurons is limited yet critical to identifying molecular pathways that lin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hayden, Eric Y., Putman, Jennifer, Nunez, Stefanie, Shin, Woo Shik, Oberoi, Mandavi, Charreton, Malena, Dutta, Suman, Li, Zizheng, Komuro, Yutaro, Joy, Mary Teena, Bitan, Gal, MacKenzie-Graham, Allan, Jiang, Lin, Hinman, Jason D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700776/ https://www.ncbi.nlm.nih.gov/pubmed/31429800 http://dx.doi.org/10.1186/s40478-019-0783-6

Ejemplares similares

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
por: Di, Jing, et al.
Publicado: (2021)

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
por: Di, Jing, et al.
Publicado: (2021)

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2019)

Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
por: Shin, Woo Shik, et al.
Publicado: (2021)

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation
por: Shin, Woo Shik, et al.
Publicado: (2019)

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges
por: Hornung, Simon, et al.
Publicado: (2020)

Editorial: Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives
por: Dutta, Suman, et al.
Publicado: (2023)

Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges
por: Dutta, Suman, et al.
Publicado: (2023)

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
por: Li, Zizheng, et al.
Publicado: (2021)

The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question—are polyphenols a viable therapeutic option against proteinopathies?
por: Bitan, Gal
Publicado: (2020)

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
por: Mandelkow, Eva-Maria, et al.
Publicado: (2004)

Editorial: Exosomes: Message in a vesicle
por: Dutta, Suman, et al.
Publicado: (2022)

Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming
por: Nakamura, Takashi, et al.
Publicado: (2023)

Prothrombotic Transformation of the Endothelium Is Markedly Augmented By Cytokine Priming and Inhibited By Tie2 Activation
por: Eaton, Nathan, et al.
Publicado: (2022)

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
por: Hilton, Brett J., et al.
Publicado: (2022)

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau
por: Zhang, Shengnan, et al.
Publicado: (2018)

Molecular Disorganization of Axons Adjacent to Human Cortical Microinfarcts
por: Coban, Hamza, et al.
Publicado: (2017)

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
por: Despres, Clément, et al.
Publicado: (2019)

Markedly Prolonged Latency of Patellar Tendon Reflex in a Patient With Apparent Acute Motor Axonal Neuropathy
por: Kwon, Ki-Han, et al.
Publicado: (2023)

Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases
por: Murakami, Kazuma, et al.
Publicado: (2021)

MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer’s disease granulovacuolar degeneration bodies
por: Lund, Harald, et al.
Publicado: (2014)

Mitochondrial fission augments capsaicin-induced axonal degeneration
por: Chiang, Hao, et al.
Publicado: (2014)

H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin
por: Chen, Ping, et al.
Publicado: (2013)

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury
por: DiBona, Victoria L., et al.
Publicado: (2019)

Long-Lasting Defence Priming by β-Aminobutyric Acid in Tomato Is Marked by Genome-Wide Changes in DNA Methylation
por: Catoni, Marco, et al.
Publicado: (2022)

A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition
por: Taha, Hash Brown, et al.
Publicado: (2022)

Effect of folic acid in prenatal alcohol induced behavioral impairment in Swiss albino mice
por: Shrestha, Uttam, et al.
Publicado: (2013)

Tau phosphorylation affects its axonal transport and degradation
por: Rodríguez-Martín, Teresa, et al.
Publicado: (2013)

Drosophila modelling axonal transport in the face of tau pathology
por: Mudher, Amrit
Publicado: (2015)

Axonal Degeneration in AD: The Contribution of Aβ and Tau
por: Salvadores, Natalia, et al.
Publicado: (2020)

Regulatory mechanisms for the axonal localization of tau protein in neurons
por: Iwata, Minori, et al.
Publicado: (2019)

Tau phosphorylation and PAD exposure in regulation of axonal growth
por: Morris, S. L., et al.
Publicado: (2023)

Extracellular Tau Oligomers Damage the Axon Initial Segment
por: Best, Merci N., et al.
Publicado: (2023)

From the Front Lines of COVID-19 at HSS: An Oral History
por: MacKenzie, C. Ronald, et al.
Publicado: (2020)

Multiport epidural catheter without port and incomplete marking
por: Gupta, Suman Lata, et al.
Publicado: (2010)

Marked expression of TNF receptors in human peritendinous tissues including in nerve fascicles with axonal damage - Studies on tendinopathy and tennis elbow
por: Spang, C., et al.
Publicado: (2017)

Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord
por: Zhai, Jinbin, et al.
Publicado: (2021)

Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis
por: Xing, Zhou, et al.
Publicado: (2009)

Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia
por: Oram, S H, et al.
Publicado: (2013)

Elevated Adrenocorticotropic Hormone, Hypercortisolism, and Marked Hypernatremia
por: Wassel, Elias, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r7ul30njcpkub11fo2oscr1o46