Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

BACKGROUND: Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. METHODS: Here we employed biochemical approaches and cellular analyses to evaluat...

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Detalles Bibliográficos
Autores principales: Gao, Juan, Bao, Yun, Ge, Shushu, Sun, Peisen, Sun, Jiaojiao, Liu, Jianmin, Chen, Feng, Han, Li, Cao, Zhongyuan, Qin, Jun, White, Gilbert C., Xu, Zhen, Ma, Yan-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700787/
https://www.ncbi.nlm.nih.gov/pubmed/31429758
http://dx.doi.org/10.1186/s12964-019-0407-6

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