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Nasal double DNA adjuvant induces salivary FimA-specific secretory IgA antibodies in young and aging mice and blocks Porphyromonas gingivalis binding to a salivary protein

BACKGROUND: We previously showed that nasal administration of a combination of dendritic cell (DC) targeted DNA plasmid expressing Flt3 ligand and CpG oligodeoxynucleotides 1826 as a mucosal adjuvant (double adjuvant, DA) provoked protective immunity in the upper respiratory tract of young adult and...

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Detalles Bibliográficos
Autores principales:	Kobuchi, Kenjiro, Kataoka, Kosuke, Taguchi, Yoichiro, Miyake, Tatsuro, Umeda, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700810/ https://www.ncbi.nlm.nih.gov/pubmed/31426773 http://dx.doi.org/10.1186/s12903-019-0886-2

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