Cargando…

Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans

BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent evidence suggests that genetic factors are related to the pathogenesis of IgAN. We conducted a genome-wide association study (GWAS) to identify novel genetic susceptibility loci for IgAN i...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Kyung Hwan, Kim, Jin Sug, Lee, Yu Ho, Kim, Yang Gyun, Moon, Ju-Young, Kim, Su Kang, Kang, Sun Woo, Kim, Tae Hee, Lee, Sang Ho, Kim, Yeong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700823/
https://www.ncbi.nlm.nih.gov/pubmed/31426789
http://dx.doi.org/10.1186/s12920-019-0568-6
_version_ 1783444939594530816
author Jeong, Kyung Hwan
Kim, Jin Sug
Lee, Yu Ho
Kim, Yang Gyun
Moon, Ju-Young
Kim, Su Kang
Kang, Sun Woo
Kim, Tae Hee
Lee, Sang Ho
Kim, Yeong Hoon
author_facet Jeong, Kyung Hwan
Kim, Jin Sug
Lee, Yu Ho
Kim, Yang Gyun
Moon, Ju-Young
Kim, Su Kang
Kang, Sun Woo
Kim, Tae Hee
Lee, Sang Ho
Kim, Yeong Hoon
author_sort Jeong, Kyung Hwan
collection PubMed
description BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent evidence suggests that genetic factors are related to the pathogenesis of IgAN. We conducted a genome-wide association study (GWAS) to identify novel genetic susceptibility loci for IgAN in a Korean population. METHODS: We enrolled 188 biopsy-confirmed IgAN cases and 455 healthy controls for the discovery stage and explored associations between IgAN and single nucleotide polymorphisms (SNPs) using a customized DNA chip. The significant SNPs from the discovery samples were then selected for replication in an independent cohort with 310 biopsy-confirmed IgAN cases and 438 healthy controls. RESULTS: In the first stage, two SNPs (rs10172700 in LOC105373592 and rs2296136 in ANKRD16) were selected for further association analysis in the next stage. In the replication cohort, rs2296136 in ANKRD16 was significantly associated with IgAN (odds ratio [OR] = 1.40, 95% confidence interval [CI] 0.99–1.98, p = 0.05 in log-additive model, OR = 1.55, 95% CI = 1.06–−2.27, p = 0.02 in dominant model, and OR = 0.70, 95% CI = 0.17–−2.84, p = 0.62 in recessive model). rs2296136 in ANKRD16 also showed a significant association with IgAN in the entire study population combining GWAS and replication study (p = 0.0045 in log-additive model, p = 0.0027 in dominant model, and p = 0.76 in recessive model). CONCLUSIONS: The SNPs identified in the present study could be good candidate markers for predicting IgAN in Koreans, although further experimental validation is needed.
format Online
Article
Text
id pubmed-6700823
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-67008232019-08-26 Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans Jeong, Kyung Hwan Kim, Jin Sug Lee, Yu Ho Kim, Yang Gyun Moon, Ju-Young Kim, Su Kang Kang, Sun Woo Kim, Tae Hee Lee, Sang Ho Kim, Yeong Hoon BMC Med Genomics Research Article BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent evidence suggests that genetic factors are related to the pathogenesis of IgAN. We conducted a genome-wide association study (GWAS) to identify novel genetic susceptibility loci for IgAN in a Korean population. METHODS: We enrolled 188 biopsy-confirmed IgAN cases and 455 healthy controls for the discovery stage and explored associations between IgAN and single nucleotide polymorphisms (SNPs) using a customized DNA chip. The significant SNPs from the discovery samples were then selected for replication in an independent cohort with 310 biopsy-confirmed IgAN cases and 438 healthy controls. RESULTS: In the first stage, two SNPs (rs10172700 in LOC105373592 and rs2296136 in ANKRD16) were selected for further association analysis in the next stage. In the replication cohort, rs2296136 in ANKRD16 was significantly associated with IgAN (odds ratio [OR] = 1.40, 95% confidence interval [CI] 0.99–1.98, p = 0.05 in log-additive model, OR = 1.55, 95% CI = 1.06–−2.27, p = 0.02 in dominant model, and OR = 0.70, 95% CI = 0.17–−2.84, p = 0.62 in recessive model). rs2296136 in ANKRD16 also showed a significant association with IgAN in the entire study population combining GWAS and replication study (p = 0.0045 in log-additive model, p = 0.0027 in dominant model, and p = 0.76 in recessive model). CONCLUSIONS: The SNPs identified in the present study could be good candidate markers for predicting IgAN in Koreans, although further experimental validation is needed. BioMed Central 2019-08-19 /pmc/articles/PMC6700823/ /pubmed/31426789 http://dx.doi.org/10.1186/s12920-019-0568-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Jeong, Kyung Hwan
Kim, Jin Sug
Lee, Yu Ho
Kim, Yang Gyun
Moon, Ju-Young
Kim, Su Kang
Kang, Sun Woo
Kim, Tae Hee
Lee, Sang Ho
Kim, Yeong Hoon
Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title_full Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title_fullStr Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title_full_unstemmed Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title_short Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
title_sort genome-wide association study identifies new susceptible loci of iga nephropathy in koreans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700823/
https://www.ncbi.nlm.nih.gov/pubmed/31426789
http://dx.doi.org/10.1186/s12920-019-0568-6
work_keys_str_mv AT jeongkyunghwan genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kimjinsug genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT leeyuho genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kimyanggyun genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT moonjuyoung genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kimsukang genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kangsunwoo genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kimtaehee genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT leesangho genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT kimyeonghoon genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans
AT genomewideassociationstudyidentifiesnewsusceptiblelociofiganephropathyinkoreans