Cargando…
Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease
Background. Anemia is common in inflammatory bowel disease (IBD). Oral iron is widely used but efficacy can be reduced by poor compliance and insufficient absorption. Intravenous iron is safe and effective in adults but is not well studied in children. Purpose. To assess safety and efficacy of intra...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700850/ https://www.ncbi.nlm.nih.gov/pubmed/31453270 http://dx.doi.org/10.1177/2333794X19870981 |
_version_ | 1783444946034884608 |
---|---|
author | Sabe, Ramy Vatsayan, Anant Mahran, Amr Khalili, Ali S. Ahuja, Sanjay Sferra, Thomas J. |
author_facet | Sabe, Ramy Vatsayan, Anant Mahran, Amr Khalili, Ali S. Ahuja, Sanjay Sferra, Thomas J. |
author_sort | Sabe, Ramy |
collection | PubMed |
description | Background. Anemia is common in inflammatory bowel disease (IBD). Oral iron is widely used but efficacy can be reduced by poor compliance and insufficient absorption. Intravenous iron is safe and effective in adults but is not well studied in children. Purpose. To assess safety and efficacy of intravenous iron sucrose (IVIS) in children with IBD. Methods. We reviewed medical records of IBD patients <22 years of age who received IVIS at our institution between 2009 and 2014. Anemia was defined as hemoglobin (Hgb) level below normal for age and gender and iron-deficiency anemia as serum iron studies and red cell mean corpuscular volume below normal ranges. Each IVIS infusion was evaluated for safety. Efficacy was defined as ≥2 g/dL increase in Hgb ≤12 weeks from IVIS initiation. Results. We identified 88 patients (Crohn’s disease, n = 52; ulcerative colitis, n = 33; IBD-unclassified, n = 3) who underwent 329 IVIS infusions over 121 courses. No patient developed anaphylaxis. Six patients developed minor adverse reactions. Of the 121 IVIS courses, 80 were included in the efficacy evaluation. There was a significant rise in Hgb (mean 9.1 ±1.4 to 11.9 ± 1.8 g/dL; P < .0001, paired t test). Overall, 58.7% (47/80 courses) resulted in goal Hgb increase. Conclusions. IVIS is safe and effective in treating iron-deficiency anemia in pediatric IBD. There were only minor adverse events, and the observed rise in Hgb was clinically significant, with the majority achieving goal Hgb. |
format | Online Article Text |
id | pubmed-6700850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67008502019-08-26 Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease Sabe, Ramy Vatsayan, Anant Mahran, Amr Khalili, Ali S. Ahuja, Sanjay Sferra, Thomas J. Glob Pediatr Health Original Article Background. Anemia is common in inflammatory bowel disease (IBD). Oral iron is widely used but efficacy can be reduced by poor compliance and insufficient absorption. Intravenous iron is safe and effective in adults but is not well studied in children. Purpose. To assess safety and efficacy of intravenous iron sucrose (IVIS) in children with IBD. Methods. We reviewed medical records of IBD patients <22 years of age who received IVIS at our institution between 2009 and 2014. Anemia was defined as hemoglobin (Hgb) level below normal for age and gender and iron-deficiency anemia as serum iron studies and red cell mean corpuscular volume below normal ranges. Each IVIS infusion was evaluated for safety. Efficacy was defined as ≥2 g/dL increase in Hgb ≤12 weeks from IVIS initiation. Results. We identified 88 patients (Crohn’s disease, n = 52; ulcerative colitis, n = 33; IBD-unclassified, n = 3) who underwent 329 IVIS infusions over 121 courses. No patient developed anaphylaxis. Six patients developed minor adverse reactions. Of the 121 IVIS courses, 80 were included in the efficacy evaluation. There was a significant rise in Hgb (mean 9.1 ±1.4 to 11.9 ± 1.8 g/dL; P < .0001, paired t test). Overall, 58.7% (47/80 courses) resulted in goal Hgb increase. Conclusions. IVIS is safe and effective in treating iron-deficiency anemia in pediatric IBD. There were only minor adverse events, and the observed rise in Hgb was clinically significant, with the majority achieving goal Hgb. SAGE Publications 2019-08-18 /pmc/articles/PMC6700850/ /pubmed/31453270 http://dx.doi.org/10.1177/2333794X19870981 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Sabe, Ramy Vatsayan, Anant Mahran, Amr Khalili, Ali S. Ahuja, Sanjay Sferra, Thomas J. Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title | Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title_full | Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title_fullStr | Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title_full_unstemmed | Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title_short | Safety and Efficacy of Intravenous Iron Sucrose for Iron-Deficiency Anemia in Children and Adolescents With Inflammatory Bowel Disease |
title_sort | safety and efficacy of intravenous iron sucrose for iron-deficiency anemia in children and adolescents with inflammatory bowel disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700850/ https://www.ncbi.nlm.nih.gov/pubmed/31453270 http://dx.doi.org/10.1177/2333794X19870981 |
work_keys_str_mv | AT saberamy safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease AT vatsayananant safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease AT mahranamr safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease AT khalilialis safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease AT ahujasanjay safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease AT sferrathomasj safetyandefficacyofintravenousironsucroseforirondeficiencyanemiainchildrenandadolescentswithinflammatoryboweldisease |