The importance of genome sequence quality to microbial comparative genomics

The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not...

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Detalles Bibliográficos
Autor principal: Smits, Theo H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701015/
https://www.ncbi.nlm.nih.gov/pubmed/31429698
http://dx.doi.org/10.1186/s12864-019-6014-5
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author Smits, Theo H. M.
author_facet Smits, Theo H. M.
author_sort Smits, Theo H. M.
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description The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not intrinsically better than the older technologies, although they are generally more efficient. In this correspondence, the importance for comparative genomics of additional manual assembly efforts over autoassembly and careful annotation is emphasized.
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spelling pubmed-67010152019-08-26 The importance of genome sequence quality to microbial comparative genomics Smits, Theo H. M. BMC Genomics Correspondence The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not intrinsically better than the older technologies, although they are generally more efficient. In this correspondence, the importance for comparative genomics of additional manual assembly efforts over autoassembly and careful annotation is emphasized. BioMed Central 2019-08-20 /pmc/articles/PMC6701015/ /pubmed/31429698 http://dx.doi.org/10.1186/s12864-019-6014-5 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Smits, Theo H. M.
The importance of genome sequence quality to microbial comparative genomics
title The importance of genome sequence quality to microbial comparative genomics
title_full The importance of genome sequence quality to microbial comparative genomics
title_fullStr The importance of genome sequence quality to microbial comparative genomics
title_full_unstemmed The importance of genome sequence quality to microbial comparative genomics
title_short The importance of genome sequence quality to microbial comparative genomics
title_sort importance of genome sequence quality to microbial comparative genomics
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701015/
https://www.ncbi.nlm.nih.gov/pubmed/31429698
http://dx.doi.org/10.1186/s12864-019-6014-5
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