The role of mRNA m(6)A methylation in the nervous system

Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for m...

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Autores principales: Li, Jiashuo, Yang, Xinxin, Qi, Zhipeng, Sang, Yanqi, Liu, Yanan, Xu, Bin, Liu, Wei, Xu, Zhaofa, Deng, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701067/
https://www.ncbi.nlm.nih.gov/pubmed/31452869
http://dx.doi.org/10.1186/s13578-019-0330-y
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author Li, Jiashuo
Yang, Xinxin
Qi, Zhipeng
Sang, Yanqi
Liu, Yanan
Xu, Bin
Liu, Wei
Xu, Zhaofa
Deng, Yu
author_facet Li, Jiashuo
Yang, Xinxin
Qi, Zhipeng
Sang, Yanqi
Liu, Yanan
Xu, Bin
Liu, Wei
Xu, Zhaofa
Deng, Yu
author_sort Li, Jiashuo
collection PubMed
description Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m(6)A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m(6)A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m(6)A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m(6)A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
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spelling pubmed-67010672019-08-26 The role of mRNA m(6)A methylation in the nervous system Li, Jiashuo Yang, Xinxin Qi, Zhipeng Sang, Yanqi Liu, Yanan Xu, Bin Liu, Wei Xu, Zhaofa Deng, Yu Cell Biosci Review Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m(6)A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m(6)A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m(6)A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m(6)A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma. BioMed Central 2019-08-20 /pmc/articles/PMC6701067/ /pubmed/31452869 http://dx.doi.org/10.1186/s13578-019-0330-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Jiashuo
Yang, Xinxin
Qi, Zhipeng
Sang, Yanqi
Liu, Yanan
Xu, Bin
Liu, Wei
Xu, Zhaofa
Deng, Yu
The role of mRNA m(6)A methylation in the nervous system
title The role of mRNA m(6)A methylation in the nervous system
title_full The role of mRNA m(6)A methylation in the nervous system
title_fullStr The role of mRNA m(6)A methylation in the nervous system
title_full_unstemmed The role of mRNA m(6)A methylation in the nervous system
title_short The role of mRNA m(6)A methylation in the nervous system
title_sort role of mrna m(6)a methylation in the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701067/
https://www.ncbi.nlm.nih.gov/pubmed/31452869
http://dx.doi.org/10.1186/s13578-019-0330-y
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