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Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

OBJECTIVE: This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS...

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Autores principales: Mohammed, Husnia Bedewi, Yismaw, Malede Berihun, Fentie, Atalay Mulu, Tadesse, Tamrat Assefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701079/
https://www.ncbi.nlm.nih.gov/pubmed/31429804
http://dx.doi.org/10.1186/s13104-019-4569-5
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author Mohammed, Husnia Bedewi
Yismaw, Malede Berihun
Fentie, Atalay Mulu
Tadesse, Tamrat Assefa
author_facet Mohammed, Husnia Bedewi
Yismaw, Malede Berihun
Fentie, Atalay Mulu
Tadesse, Tamrat Assefa
author_sort Mohammed, Husnia Bedewi
collection PubMed
description OBJECTIVE: This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. RESULTS: Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.8% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2 (1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm(3) in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN.
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spelling pubmed-67010792019-08-26 Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital Mohammed, Husnia Bedewi Yismaw, Malede Berihun Fentie, Atalay Mulu Tadesse, Tamrat Assefa BMC Res Notes Research Note OBJECTIVE: This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. RESULTS: Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.8% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2 (1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm(3) in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN. BioMed Central 2019-08-20 /pmc/articles/PMC6701079/ /pubmed/31429804 http://dx.doi.org/10.1186/s13104-019-4569-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Mohammed, Husnia Bedewi
Yismaw, Malede Berihun
Fentie, Atalay Mulu
Tadesse, Tamrat Assefa
Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title_full Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title_fullStr Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title_full_unstemmed Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title_short Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital
title_sort febrile neutropenia management in pediatric cancer patients at ethiopian tertiary care teaching hospital
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701079/
https://www.ncbi.nlm.nih.gov/pubmed/31429804
http://dx.doi.org/10.1186/s13104-019-4569-5
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