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Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells

Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has long been a topic of debate. The terms “type B synoviocytes,” “fibroblast-like synoviocytes...

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Autores principales: Li, Fangqi, Tang, Yiyong, Song, Bin, Yu, Menglei, Li, Qingyue, Zhang, Congda, Hou, Jingyi, Yang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701095/
https://www.ncbi.nlm.nih.gov/pubmed/31426847
http://dx.doi.org/10.1186/s13287-019-1359-x
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author Li, Fangqi
Tang, Yiyong
Song, Bin
Yu, Menglei
Li, Qingyue
Zhang, Congda
Hou, Jingyi
Yang, Rui
author_facet Li, Fangqi
Tang, Yiyong
Song, Bin
Yu, Menglei
Li, Qingyue
Zhang, Congda
Hou, Jingyi
Yang, Rui
author_sort Li, Fangqi
collection PubMed
description Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has long been a topic of debate. The terms “type B synoviocytes,” “fibroblast-like synoviocytes (FLS),” “synovium-derived mesenchymal stem cells (MSCs),” and “synovial fibroblasts (SF)” appeared in different articles related to human synovial-derived cells in various disease models, yet they seemed to be describing the same cell type. However, to date, there is no clear standard to distinguish these terms; thus, the hypothesis that they represent the same cell type is currently inconclusive. Therefore, this review aims to clarify the similarities and differences between these terms and to diffuse the chaotic nomenclature of synovial-derived cells.
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spelling pubmed-67010952019-08-26 Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells Li, Fangqi Tang, Yiyong Song, Bin Yu, Menglei Li, Qingyue Zhang, Congda Hou, Jingyi Yang, Rui Stem Cell Res Ther Review Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has long been a topic of debate. The terms “type B synoviocytes,” “fibroblast-like synoviocytes (FLS),” “synovium-derived mesenchymal stem cells (MSCs),” and “synovial fibroblasts (SF)” appeared in different articles related to human synovial-derived cells in various disease models, yet they seemed to be describing the same cell type. However, to date, there is no clear standard to distinguish these terms; thus, the hypothesis that they represent the same cell type is currently inconclusive. Therefore, this review aims to clarify the similarities and differences between these terms and to diffuse the chaotic nomenclature of synovial-derived cells. BioMed Central 2019-08-19 /pmc/articles/PMC6701095/ /pubmed/31426847 http://dx.doi.org/10.1186/s13287-019-1359-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Fangqi
Tang, Yiyong
Song, Bin
Yu, Menglei
Li, Qingyue
Zhang, Congda
Hou, Jingyi
Yang, Rui
Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title_full Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title_fullStr Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title_full_unstemmed Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title_short Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
title_sort nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701095/
https://www.ncbi.nlm.nih.gov/pubmed/31426847
http://dx.doi.org/10.1186/s13287-019-1359-x
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