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Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder
Insomnia is a type of sleep disorder which is associated with various diseases’ development and progression, such as obesity, type II diabetes and cardiovascular diseases. Recent investigation of the gut-brain axis enhances our understanding of the role of the gut microbiota in brain-related disease...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701205/ https://www.ncbi.nlm.nih.gov/pubmed/31456757 http://dx.doi.org/10.3389/fmicb.2019.01770 |
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author | Liu, Bingdong Lin, Weifeng Chen, Shujie Xiang, Ting Yang, Yifan Yin, Yulong Xu, Guohuan Liu, Zhihong Liu, Li Pan, Jiyang Xie, Liwei |
author_facet | Liu, Bingdong Lin, Weifeng Chen, Shujie Xiang, Ting Yang, Yifan Yin, Yulong Xu, Guohuan Liu, Zhihong Liu, Li Pan, Jiyang Xie, Liwei |
author_sort | Liu, Bingdong |
collection | PubMed |
description | Insomnia is a type of sleep disorder which is associated with various diseases’ development and progression, such as obesity, type II diabetes and cardiovascular diseases. Recent investigation of the gut-brain axis enhances our understanding of the role of the gut microbiota in brain-related diseases. However, whether the gut microbiota is associated with insomnia remains unknown. In the present investigation, leveraging the 16S rDNA amplicon sequencing of V3-V4 region and the novel bioinformatic analysis, it was demonstrated that between insomnia and healthy populations, the composition, diversity and metabolic function of the gut microbiota are significantly changed. Other than these, redundancy analysis, co-occurrence analysis and PICRUSt underpin the gut taxa composition, signaling pathways, and metabolic functions perturbed by insomnia disorder. Moreover, random forest together with cross-validation identified two signature bacteria, which could be used to distinguish the insomnia patients from the healthy population. Furthermore, based on the relative abundance and clinical sleep parameter, we constructed a prediction model utilizing artificial neural network (ANN) for auxiliary diagnosis of insomnia disorder. Overall, the aforementioned study provides a comprehensive understanding of the link between the gut microbiota and insomnia disorder. |
format | Online Article Text |
id | pubmed-6701205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67012052019-08-27 Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder Liu, Bingdong Lin, Weifeng Chen, Shujie Xiang, Ting Yang, Yifan Yin, Yulong Xu, Guohuan Liu, Zhihong Liu, Li Pan, Jiyang Xie, Liwei Front Microbiol Microbiology Insomnia is a type of sleep disorder which is associated with various diseases’ development and progression, such as obesity, type II diabetes and cardiovascular diseases. Recent investigation of the gut-brain axis enhances our understanding of the role of the gut microbiota in brain-related diseases. However, whether the gut microbiota is associated with insomnia remains unknown. In the present investigation, leveraging the 16S rDNA amplicon sequencing of V3-V4 region and the novel bioinformatic analysis, it was demonstrated that between insomnia and healthy populations, the composition, diversity and metabolic function of the gut microbiota are significantly changed. Other than these, redundancy analysis, co-occurrence analysis and PICRUSt underpin the gut taxa composition, signaling pathways, and metabolic functions perturbed by insomnia disorder. Moreover, random forest together with cross-validation identified two signature bacteria, which could be used to distinguish the insomnia patients from the healthy population. Furthermore, based on the relative abundance and clinical sleep parameter, we constructed a prediction model utilizing artificial neural network (ANN) for auxiliary diagnosis of insomnia disorder. Overall, the aforementioned study provides a comprehensive understanding of the link between the gut microbiota and insomnia disorder. Frontiers Media S.A. 2019-08-13 /pmc/articles/PMC6701205/ /pubmed/31456757 http://dx.doi.org/10.3389/fmicb.2019.01770 Text en Copyright © 2019 Liu, Lin, Chen, Xiang, Yang, Yin, Xu, Liu, Liu, Pan and Xie. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Liu, Bingdong Lin, Weifeng Chen, Shujie Xiang, Ting Yang, Yifan Yin, Yulong Xu, Guohuan Liu, Zhihong Liu, Li Pan, Jiyang Xie, Liwei Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title | Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title_full | Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title_fullStr | Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title_full_unstemmed | Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title_short | Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder |
title_sort | gut microbiota as an objective measurement for auxiliary diagnosis of insomnia disorder |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701205/ https://www.ncbi.nlm.nih.gov/pubmed/31456757 http://dx.doi.org/10.3389/fmicb.2019.01770 |
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