Cargando…

Primary Tumor Site Specificity is Preserved in Patient-Derived Tumor Xenograft Models

Patient-derived tumor xenograft (PDX) mouse models are widely used for drug screening. The underlying assumption is that PDX tissue is very similar with the original patient tissue, and it has the same response to the drug treatment. To investigate whether the primary tumor site information is well...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lei, Pan, Xiaoyong, Zhang, Yu-Hang, Hu, Xiaohua, Feng, KaiYan, Huang, Tao, Cai, Yu-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701289/ https://www.ncbi.nlm.nih.gov/pubmed/31456818 http://dx.doi.org/10.3389/fgene.2019.00738

Ejemplares similares

Alternative Polyadenylation Modification Patterns Reveal Essential Posttranscription Regulatory Mechanisms of Tumorigenesis in Multiple Tumor Types
por: Li, Min, et al.
Publicado: (2020)

Distinguishing Glioblastoma Subtypes by Methylation Signatures
por: Zhang, Yu-Hang, et al.
Publicado: (2020)

Identification of Gene Signatures and Expression Patterns During Epithelial-to-Mesenchymal Transition From Single-Cell Expression Atlas
por: Yu, Xiangtian, et al.
Publicado: (2021)

Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling
por: Patel, Shovik S., et al.
Publicado: (2021)

Identifying Key MicroRNA Signatures for Neurodegenerative Diseases With Machine Learning Methods
por: Li, ZhanDong, et al.
Publicado: (2022)

Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles
por: Zhang, Yu-Hang, et al.
Publicado: (2021)

Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure
por: Colombo, Pierre-Emmanuel, et al.
Publicado: (2015)

Identification of Protein Subcellular Localization With Network and Functional Embeddings
por: Pan, Xiaoyong, et al.
Publicado: (2021)

Identifying Patients with Atrioventricular Septal Defect in Down Syndrome Populations by Using Self-Normalizing Neural Networks and Feature Selection
por: Pan, Xiaoyong, et al.
Publicado: (2018)

Patient-derived xenografts undergo murine-specific tumor evolution
por: Ben-David, Uri, et al.
Publicado: (2017)

Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts
por: Vincent, Jason, et al.
Publicado: (2021)

Identifying Functions of Proteins in Mice With Functional Embedding Features
por: Li, Hao, et al.
Publicado: (2022)

Identification of COVID-19 severity biomarkers based on feature selection on single-cell RNA-Seq data of CD8(+) T cells
por: Lu, Jian, et al.
Publicado: (2022)

Characterization of chromatin accessibility patterns in different mouse cell types using machine learning methods at single-cell resolution
por: Xu, Yaochen, et al.
Publicado: (2023)

Pan-Cancer DNA Methylation Analysis and Tumor Origin Identification of Carcinoma of Unknown Primary Site Based on Multi-Omics
por: Liu, Pengfei
Publicado: (2022)

Investigation and Prediction of Human Interactome Based on Quantitative Features
por: Pan, Xiaoyong, et al.
Publicado: (2020)

Identification of the Gene Expression Rules That Define the Subtypes in Glioma
por: Cai, Yu-Dong, et al.
Publicado: (2018)

Applications of patient-derived tumor xenograft models and tumor organoids
por: Yoshida, Go J.
Publicado: (2020)

Comparison of Proteomics Profiles Between Xenografts Derived from Cell Lines and Primary Tumors of Thyroid Carcinoma
por: Fang, Luo, et al.
Publicado: (2021)

RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development
por: Elchuri, Sailaja V., et al.
Publicado: (2018)

Pre-clinical Models for Malignant Mesothelioma Research: From Chemical-Induced to Patient-Derived Cancer Xenografts
por: Nabavi, Noushin, et al.
Publicado: (2018)

Immune responses of different COVID-19 vaccination strategies by analyzing single-cell RNA sequencing data from multiple tissues using machine learning methods
por: Li, Hao, et al.
Publicado: (2023)

Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis
por: Bai, Suwen, et al.
Publicado: (2022)

Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors()
por: Bondarenko, Gennadiy, et al.
Publicado: (2015)

Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning Methods
por: Chen, Lei, et al.
Publicado: (2021)

Characteristics of malignant tumors of digestive system and autoimmune diseases
por: Yin, Hang, et al.
Publicado: (2023)

Case Report: Triple Primary Malignant Tumors of the Esophagus, Stomach, and Colon in a Patient With Genetic Analysis
por: Zhan, Xiaoli, et al.
Publicado: (2021)

Establishment of Novel Gastric Cancer Patient-Derived Xenografts and Cell Lines: Pathological Comparison between Primary Tumor, Patient-Derived, and Cell-Line Derived Xenografts
por: Kuwata, Takeshi, et al.
Publicado: (2019)

Machine Learning Models to Predict Primary Sites of Metastatic Cervical Carcinoma From Unknown Primary
por: Lu, Di, et al.
Publicado: (2020)

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors
por: Stewart, Elizabeth, et al.
Publicado: (2017)

Single-cell analysis technologies for cancer research: from tumor-specific single cell discovery to cancer therapy
por: Chen, Siyuan, et al.
Publicado: (2023)

Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse
por: Rijensky, Nataly Mancette, et al.
Publicado: (2020)

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors
por: Blumer, Tanja, et al.
Publicado: (2019)

Establishment and Characterization of Feline Mammary Tumor Patient-Derived Xenograft Model
por: Chuang, Hsiao-Li, et al.
Publicado: (2021)

Identification and Validation of Immune-Related Prognostic Genes in the Tumor Microenvironment of Colon Adenocarcinoma
por: Pan, Shenghua, et al.
Publicado: (2022)

Association of Tumor Budding With Immune Evasion Pathways in Primary Colorectal Cancer and Patient-Derived Xenografts
por: Guil-Luna, Silvia, et al.
Publicado: (2020)

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
por: Shen, Qiyang, et al.
Publicado: (2022)

Discriminating Origin Tissues of Tumor Cell Lines by Methylation Signatures and Dys-Methylated Rules
por: Zhang, Shiqi, et al.
Publicado: (2020)

i5hmCVec: Identifying 5-Hydroxymethylcytosine Sites of Drosophila RNA Using Sequence Feature Embeddings
por: Liu, Hang-Yu, et al.
Publicado: (2022)

CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases
por: Liu, Tong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j0vhsjo8rcn6o6mqrn4876pj54