Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients

INTRODUCTION: Schizophrenia (SZ) increases the level of cell death, leading to an increase in the concentration of circulating cell-free DNA (cfDNA). Ribosomal DNA (rDNA) contains many unmethylated CpG motifs that stimulate TLR9-MyD88-NF-κB signaling and the synthesis of proinflammatory cytokines. T...

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Detalles Bibliográficos
Autores principales: Ershova, E. S., Jestkova, E. M., Martynov, A. V., Shmarina, G. V., Umriukhin, P. E., Bravve, L. V., Zakharova, N. V., Kostyuk, G. P., Saveliev, D. V., Orlova, M. D., Bogush, M., Kutsev, S. I., Veiko, N. N., Kostyuk, S. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701307/
https://www.ncbi.nlm.nih.gov/pubmed/31467866
http://dx.doi.org/10.1155/2019/8390585

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