Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)

This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was collected from patients with T1D and healthy control participants. Expression o...

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Autores principales: An, Jingnan, Ding, Sisi, Li, Sicheng, Sun, Lili, Chang, Xin, Huang, Ziyi, Zhou, Bin, Fang, Chen, Liu, Cuiping, Zhang, Xueguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701347/
https://www.ncbi.nlm.nih.gov/pubmed/31467932
http://dx.doi.org/10.1155/2019/1780567
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author An, Jingnan
Ding, Sisi
Li, Sicheng
Sun, Lili
Chang, Xin
Huang, Ziyi
Zhou, Bin
Fang, Chen
Liu, Cuiping
Zhang, Xueguang
author_facet An, Jingnan
Ding, Sisi
Li, Sicheng
Sun, Lili
Chang, Xin
Huang, Ziyi
Zhou, Bin
Fang, Chen
Liu, Cuiping
Zhang, Xueguang
author_sort An, Jingnan
collection PubMed
description This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was collected from patients with T1D and healthy control participants. Expression of mOX40 and mOX40L on immune cells was detected by flow cytometry. Levels of sOX40 and sOX40L in sera were measured by ELISA. We demonstrated for the first time enhanced sOX40 and sOX40L expression and reduced mOX40 and mOX40L levels in T1D patients which correlated with the clinical characteristics and inflammatory factors. These results suggest that OX40/OX40L signal may be promising biomarkers and associated with the pathogenesis of T1D.
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spelling pubmed-67013472019-08-29 Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D) An, Jingnan Ding, Sisi Li, Sicheng Sun, Lili Chang, Xin Huang, Ziyi Zhou, Bin Fang, Chen Liu, Cuiping Zhang, Xueguang J Immunol Res Research Article This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was collected from patients with T1D and healthy control participants. Expression of mOX40 and mOX40L on immune cells was detected by flow cytometry. Levels of sOX40 and sOX40L in sera were measured by ELISA. We demonstrated for the first time enhanced sOX40 and sOX40L expression and reduced mOX40 and mOX40L levels in T1D patients which correlated with the clinical characteristics and inflammatory factors. These results suggest that OX40/OX40L signal may be promising biomarkers and associated with the pathogenesis of T1D. Hindawi 2019-08-01 /pmc/articles/PMC6701347/ /pubmed/31467932 http://dx.doi.org/10.1155/2019/1780567 Text en Copyright © 2019 Jingnan An et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
An, Jingnan
Ding, Sisi
Li, Sicheng
Sun, Lili
Chang, Xin
Huang, Ziyi
Zhou, Bin
Fang, Chen
Liu, Cuiping
Zhang, Xueguang
Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title_full Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title_fullStr Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title_full_unstemmed Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title_short Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
title_sort enhancement of the soluble form of ox40 and ox40l costimulatory molecules but reduction of the membrane form in type 1 diabetes (t1d)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701347/
https://www.ncbi.nlm.nih.gov/pubmed/31467932
http://dx.doi.org/10.1155/2019/1780567
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