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Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is thought to play a significant role in the advancement to chronic kidney disease and contributes to the deposition of extracellular matrix proteins and renal fibrosis relating to diabetic nephropathy. METHOD: We studied the effect of Nrf2-HO-1...

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Detalles Bibliográficos
Autores principales:	Shin, Jong Ho, Kim, Kyeong Min, Jeong, Jin Uk, Shin, Jae Min, Kang, Ju Hyung, Bang, Kitae, Kim, Joo-Heon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701369/ https://www.ncbi.nlm.nih.gov/pubmed/31467925 http://dx.doi.org/10.1155/2019/2510105

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