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Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy
PURPOSE: The aim of this cross-sectional study was to characterize and compare the retinal vasculature and microstructure in patients with early dry-type myopic maculopathy. METHODS: Patients with a refractive error of less than −6 diopters were enrolled and classified into two groups. Group 1 compr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701411/ https://www.ncbi.nlm.nih.gov/pubmed/31467694 http://dx.doi.org/10.1155/2019/7540897 |
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author | Sun, Jiao Wang, Jialin Wang, Yanling |
author_facet | Sun, Jiao Wang, Jialin Wang, Yanling |
author_sort | Sun, Jiao |
collection | PubMed |
description | PURPOSE: The aim of this cross-sectional study was to characterize and compare the retinal vasculature and microstructure in patients with early dry-type myopic maculopathy. METHODS: Patients with a refractive error of less than −6 diopters were enrolled and classified into two groups. Group 1 comprised 82 eyes with a tessellated fundus, and group 2 comprised 56 eyes with diffuse chorioretinal atrophy (DCA). The clinical characteristics, refractive error, axial length, retinal vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), macular choroidal thickness, and best-corrected visual acuity (BCVA), were compared between the groups. Logistic regression was used to determine the protective and risk factors for DCA. RESULTS: Group 1 patients were significantly younger and had better BCVA, less myopia, and shorter axial length than group 2 patients. The vessel densities of the SCP and DCP, choroidal thickness, retinal nerve fiber layer thickness, ganglion cell complex thickness, and retinal thickness were reduced in group 2. Multiple logistic regression analysis revealed that the vessel densities of the SCP and DCP were protective factors for DCA. CONCLUSIONS: The vessel density of the SCP had the highest diagnostic value (sensitivity = 78.0% and specificity = 96.6%). When the SCP vessel density was reduced to ≤49.98%, DCA was indicated. The retinal vessel densities of the SCP and DCP and parameters of the microstructure were reduced significantly in patients with DCA. Vessel density may be a better diagnostic indicator of the development of DCA. |
format | Online Article Text |
id | pubmed-6701411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-67014112019-08-29 Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy Sun, Jiao Wang, Jialin Wang, Yanling J Ophthalmol Research Article PURPOSE: The aim of this cross-sectional study was to characterize and compare the retinal vasculature and microstructure in patients with early dry-type myopic maculopathy. METHODS: Patients with a refractive error of less than −6 diopters were enrolled and classified into two groups. Group 1 comprised 82 eyes with a tessellated fundus, and group 2 comprised 56 eyes with diffuse chorioretinal atrophy (DCA). The clinical characteristics, refractive error, axial length, retinal vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), macular choroidal thickness, and best-corrected visual acuity (BCVA), were compared between the groups. Logistic regression was used to determine the protective and risk factors for DCA. RESULTS: Group 1 patients were significantly younger and had better BCVA, less myopia, and shorter axial length than group 2 patients. The vessel densities of the SCP and DCP, choroidal thickness, retinal nerve fiber layer thickness, ganglion cell complex thickness, and retinal thickness were reduced in group 2. Multiple logistic regression analysis revealed that the vessel densities of the SCP and DCP were protective factors for DCA. CONCLUSIONS: The vessel density of the SCP had the highest diagnostic value (sensitivity = 78.0% and specificity = 96.6%). When the SCP vessel density was reduced to ≤49.98%, DCA was indicated. The retinal vessel densities of the SCP and DCP and parameters of the microstructure were reduced significantly in patients with DCA. Vessel density may be a better diagnostic indicator of the development of DCA. Hindawi 2019-08-05 /pmc/articles/PMC6701411/ /pubmed/31467694 http://dx.doi.org/10.1155/2019/7540897 Text en Copyright © 2019 Jiao Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sun, Jiao Wang, Jialin Wang, Yanling Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title | Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title_full | Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title_fullStr | Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title_full_unstemmed | Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title_short | Retinal Vasculature and Microstructure in Early Dry-Type Myopic Maculopathy |
title_sort | retinal vasculature and microstructure in early dry-type myopic maculopathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701411/ https://www.ncbi.nlm.nih.gov/pubmed/31467694 http://dx.doi.org/10.1155/2019/7540897 |
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