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Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol
INTRODUCTION: This study aims to investigate patterns of antibiotic treatment-seeking, describe current levels of and drivers for antibiotic use for common infections (respiratory tract and urinary tract infections) and test the feasibility of determining the prevalence and epidemiology of antimicro...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701592/ https://www.ncbi.nlm.nih.gov/pubmed/31401593 http://dx.doi.org/10.1136/bmjopen-2018-027819 |
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author | Zhao, Linhai Kwiatkowska, Rachel Marie Chai, Jing Cabral, Christie Chen, Meixuan Bowker, Karen Coope, Caroline Shen, Jilu Shen, XingRong Cheng, Jing Feng, Rui Kadetz, Paul MacGowan, Alasdair Oliver, Isabel Hickman, Matthew Wang, Debin Lambert, Helen |
author_facet | Zhao, Linhai Kwiatkowska, Rachel Marie Chai, Jing Cabral, Christie Chen, Meixuan Bowker, Karen Coope, Caroline Shen, Jilu Shen, XingRong Cheng, Jing Feng, Rui Kadetz, Paul MacGowan, Alasdair Oliver, Isabel Hickman, Matthew Wang, Debin Lambert, Helen |
author_sort | Zhao, Linhai |
collection | PubMed |
description | INTRODUCTION: This study aims to investigate patterns of antibiotic treatment-seeking, describe current levels of and drivers for antibiotic use for common infections (respiratory tract and urinary tract infections) and test the feasibility of determining the prevalence and epidemiology of antimicrobial resistance (AMR) in rural areas of Anhui province, in order to identify potential interventions to promote antibiotic stewardship and reduce the burden of AMR in China. METHODS AND ANALYSIS: We will conduct direct observations, structured and semistructured interviews in retail pharmacies, village clinics and township health centres to investigate treatment-seeking and antibiotic use. Clinical isolates from 1550 sputum, throat swab and urine samples taken from consenting patients at village and township health centres will be analysed to identify bacterial pathogens and ascertain antibiotic susceptibilities. Healthcare records will be surveyed for a subsample of those recruited to the study to assess their completeness and accuracy. ETHICS AND DISSEMINATION: The full research protocol has been reviewed and approved by the Biomedical Ethics Committee of Anhui Medical University (reference number: 20170271). Participation of patients and doctors is voluntary and written informed consent is sought from all participants. Findings from the study will be disseminated through academic routes including peer-reviewed publications and conference presentations, via tailored research summaries for health professionals, health service managers and policymakers and through an end of project impact workshop with local and regional stakeholders to identify key messages and priorities for action. |
format | Online Article Text |
id | pubmed-6701592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67015922019-09-02 Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol Zhao, Linhai Kwiatkowska, Rachel Marie Chai, Jing Cabral, Christie Chen, Meixuan Bowker, Karen Coope, Caroline Shen, Jilu Shen, XingRong Cheng, Jing Feng, Rui Kadetz, Paul MacGowan, Alasdair Oliver, Isabel Hickman, Matthew Wang, Debin Lambert, Helen BMJ Open Global Health INTRODUCTION: This study aims to investigate patterns of antibiotic treatment-seeking, describe current levels of and drivers for antibiotic use for common infections (respiratory tract and urinary tract infections) and test the feasibility of determining the prevalence and epidemiology of antimicrobial resistance (AMR) in rural areas of Anhui province, in order to identify potential interventions to promote antibiotic stewardship and reduce the burden of AMR in China. METHODS AND ANALYSIS: We will conduct direct observations, structured and semistructured interviews in retail pharmacies, village clinics and township health centres to investigate treatment-seeking and antibiotic use. Clinical isolates from 1550 sputum, throat swab and urine samples taken from consenting patients at village and township health centres will be analysed to identify bacterial pathogens and ascertain antibiotic susceptibilities. Healthcare records will be surveyed for a subsample of those recruited to the study to assess their completeness and accuracy. ETHICS AND DISSEMINATION: The full research protocol has been reviewed and approved by the Biomedical Ethics Committee of Anhui Medical University (reference number: 20170271). Participation of patients and doctors is voluntary and written informed consent is sought from all participants. Findings from the study will be disseminated through academic routes including peer-reviewed publications and conference presentations, via tailored research summaries for health professionals, health service managers and policymakers and through an end of project impact workshop with local and regional stakeholders to identify key messages and priorities for action. BMJ Publishing Group 2019-08-10 /pmc/articles/PMC6701592/ /pubmed/31401593 http://dx.doi.org/10.1136/bmjopen-2018-027819 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Global Health Zhao, Linhai Kwiatkowska, Rachel Marie Chai, Jing Cabral, Christie Chen, Meixuan Bowker, Karen Coope, Caroline Shen, Jilu Shen, XingRong Cheng, Jing Feng, Rui Kadetz, Paul MacGowan, Alasdair Oliver, Isabel Hickman, Matthew Wang, Debin Lambert, Helen Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title | Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title_full | Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title_fullStr | Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title_full_unstemmed | Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title_short | Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol |
title_sort | pathways to optimising antibiotic use in rural china: identifying key determinants in community and clinical settings, a mixed methods study protocol |
topic | Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701592/ https://www.ncbi.nlm.nih.gov/pubmed/31401593 http://dx.doi.org/10.1136/bmjopen-2018-027819 |
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