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Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis
BACKGROUND: The RAS family of oncogenes (KRAS, HRAS, NRAS) are the most frequent mutations in cancers and regulate key signaling pathways that drive tumor progression. As a result, drug delivery targeting RAS-driven tumors has been a long-standing challenge in cancer therapy. Mutant RAS activates ca...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701665/ https://www.ncbi.nlm.nih.gov/pubmed/31496700 http://dx.doi.org/10.2147/IJN.S212861 |