TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

During autophagy, phagophores grow into doublemembrane vesicles called autophagosomes, but the underlying mechanism remains unclear. Here, we show a critical role of Atg2A in phagophore expansion. Atg2A translocates to the phagophore at the mitochondria-associated ER membrane (MAM) through a C-termi...

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Detalles Bibliográficos
Autores principales: Tang, Zhenyuan, Takahashi, Yoshinori, He, Haiyan, Hattori, Tatsuya, Chen, Chong, Liang, Xinwen, Chen, Han, Young, Megan M., Wang, Hong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701867/
https://www.ncbi.nlm.nih.gov/pubmed/31412244
http://dx.doi.org/10.1016/j.celrep.2019.07.036

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