Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations

Primary chest wall lymphoma is rare and typically associated with chronic pleural inflammation. Double-hit lymphoma (DHL), which is defined as aggressive mature B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements, is a highly aggressive malignancy that tends to have extranodal involvement and i...

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Detalles Bibliográficos
Autores principales: Kamachi, Kazuharu, Kubota, Yasushi, Nagaie, Toshiaki, Yamaguchi, Kyosuke, Ogusu, Shinsuke, Kidoguchi, Keisuke, Kusaba, Kana, Kizuka-Sano, Haruna, Nishioka, Atsujiro, Yoshimura, Mariko, Yokoo, Masako, Ando, Toshihiko, Kai, Keita, Kojima, Kensuke, Ohshima, Koichi, Sueoka, Eisaburo, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702014/
https://www.ncbi.nlm.nih.gov/pubmed/30918199
http://dx.doi.org/10.2169/internalmedicine.2532-18
Descripción
Sumario:Primary chest wall lymphoma is rare and typically associated with chronic pleural inflammation. Double-hit lymphoma (DHL), which is defined as aggressive mature B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements, is a highly aggressive malignancy that tends to have extranodal involvement and is resistant to standard immunochemotherapy. We herein report a 55-year-old man with no history of chronic pleural inflammation, diagnosed with primary chest wall DHL with MYC/BCL6 rearrangement, and harboring a unique BCL6 translocation, t(3;7)(q27;p12). After six courses of intensive chemotherapy, he has achieved complete remission. To our knowledge, this is the first case report of primary chest wall DHL.

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