Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations

Primary chest wall lymphoma is rare and typically associated with chronic pleural inflammation. Double-hit lymphoma (DHL), which is defined as aggressive mature B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements, is a highly aggressive malignancy that tends to have extranodal involvement and i...

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Autores principales: Kamachi, Kazuharu, Kubota, Yasushi, Nagaie, Toshiaki, Yamaguchi, Kyosuke, Ogusu, Shinsuke, Kidoguchi, Keisuke, Kusaba, Kana, Kizuka-Sano, Haruna, Nishioka, Atsujiro, Yoshimura, Mariko, Yokoo, Masako, Ando, Toshihiko, Kai, Keita, Kojima, Kensuke, Ohshima, Koichi, Sueoka, Eisaburo, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702014/
https://www.ncbi.nlm.nih.gov/pubmed/30918199
http://dx.doi.org/10.2169/internalmedicine.2532-18
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author Kamachi, Kazuharu
Kubota, Yasushi
Nagaie, Toshiaki
Yamaguchi, Kyosuke
Ogusu, Shinsuke
Kidoguchi, Keisuke
Kusaba, Kana
Kizuka-Sano, Haruna
Nishioka, Atsujiro
Yoshimura, Mariko
Yokoo, Masako
Ando, Toshihiko
Kai, Keita
Kojima, Kensuke
Ohshima, Koichi
Sueoka, Eisaburo
Kimura, Shinya
author_facet Kamachi, Kazuharu
Kubota, Yasushi
Nagaie, Toshiaki
Yamaguchi, Kyosuke
Ogusu, Shinsuke
Kidoguchi, Keisuke
Kusaba, Kana
Kizuka-Sano, Haruna
Nishioka, Atsujiro
Yoshimura, Mariko
Yokoo, Masako
Ando, Toshihiko
Kai, Keita
Kojima, Kensuke
Ohshima, Koichi
Sueoka, Eisaburo
Kimura, Shinya
author_sort Kamachi, Kazuharu
collection PubMed
description Primary chest wall lymphoma is rare and typically associated with chronic pleural inflammation. Double-hit lymphoma (DHL), which is defined as aggressive mature B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements, is a highly aggressive malignancy that tends to have extranodal involvement and is resistant to standard immunochemotherapy. We herein report a 55-year-old man with no history of chronic pleural inflammation, diagnosed with primary chest wall DHL with MYC/BCL6 rearrangement, and harboring a unique BCL6 translocation, t(3;7)(q27;p12). After six courses of intensive chemotherapy, he has achieved complete remission. To our knowledge, this is the first case report of primary chest wall DHL.
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spelling pubmed-67020142019-08-21 Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations Kamachi, Kazuharu Kubota, Yasushi Nagaie, Toshiaki Yamaguchi, Kyosuke Ogusu, Shinsuke Kidoguchi, Keisuke Kusaba, Kana Kizuka-Sano, Haruna Nishioka, Atsujiro Yoshimura, Mariko Yokoo, Masako Ando, Toshihiko Kai, Keita Kojima, Kensuke Ohshima, Koichi Sueoka, Eisaburo Kimura, Shinya Intern Med Case Report Primary chest wall lymphoma is rare and typically associated with chronic pleural inflammation. Double-hit lymphoma (DHL), which is defined as aggressive mature B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements, is a highly aggressive malignancy that tends to have extranodal involvement and is resistant to standard immunochemotherapy. We herein report a 55-year-old man with no history of chronic pleural inflammation, diagnosed with primary chest wall DHL with MYC/BCL6 rearrangement, and harboring a unique BCL6 translocation, t(3;7)(q27;p12). After six courses of intensive chemotherapy, he has achieved complete remission. To our knowledge, this is the first case report of primary chest wall DHL. The Japanese Society of Internal Medicine 2019-03-28 2019-07-15 /pmc/articles/PMC6702014/ /pubmed/30918199 http://dx.doi.org/10.2169/internalmedicine.2532-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kamachi, Kazuharu
Kubota, Yasushi
Nagaie, Toshiaki
Yamaguchi, Kyosuke
Ogusu, Shinsuke
Kidoguchi, Keisuke
Kusaba, Kana
Kizuka-Sano, Haruna
Nishioka, Atsujiro
Yoshimura, Mariko
Yokoo, Masako
Ando, Toshihiko
Kai, Keita
Kojima, Kensuke
Ohshima, Koichi
Sueoka, Eisaburo
Kimura, Shinya
Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title_full Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title_fullStr Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title_full_unstemmed Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title_short Primary Chest Wall MYC/BCL6 Double-hit Lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) Translocations
title_sort primary chest wall myc/bcl6 double-hit lymphoma with t(3;7)(q27;p12) and t(8;14)(q24;q32) translocations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702014/
https://www.ncbi.nlm.nih.gov/pubmed/30918199
http://dx.doi.org/10.2169/internalmedicine.2532-18
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