A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria

A 21-year-old woman presented with renal dysfunction during macrohematuria. A kidney biopsy revealed IgA nephropathy with a small percentage of crescent formation and macrohematuria-associated tubular injury. Macrohematuria-associated acute kidney injury could explain her renal dysfunction. However,...

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Autores principales: Yasukawa, Minoru, Kitagawa, Sachiko, Togashi, Ryo, Asakawa, Shinichiro, Nagura, Michito, Arai, Shigeyuki, Yamazaki, Osamu, Tamura, Yoshifuru, Kondo, Fukuo, Ohashi, Ryuji, Uchida, Shunya, Shibata, Shigeru, Fujigaki, Yoshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702016/
https://www.ncbi.nlm.nih.gov/pubmed/30918194
http://dx.doi.org/10.2169/internalmedicine.2475-18
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author Yasukawa, Minoru
Kitagawa, Sachiko
Togashi, Ryo
Asakawa, Shinichiro
Nagura, Michito
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Kondo, Fukuo
Ohashi, Ryuji
Uchida, Shunya
Shibata, Shigeru
Fujigaki, Yoshihide
author_facet Yasukawa, Minoru
Kitagawa, Sachiko
Togashi, Ryo
Asakawa, Shinichiro
Nagura, Michito
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Kondo, Fukuo
Ohashi, Ryuji
Uchida, Shunya
Shibata, Shigeru
Fujigaki, Yoshihide
author_sort Yasukawa, Minoru
collection PubMed
description A 21-year-old woman presented with renal dysfunction during macrohematuria. A kidney biopsy revealed IgA nephropathy with a small percentage of crescent formation and macrohematuria-associated tubular injury. Macrohematuria-associated acute kidney injury could explain her renal dysfunction. However, she was seropositive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) and showed fibrin deposition around one arteriole. Corticosteroids and mycophenolate mofetil were administered as for ANCA vasculitis, and the serum creatinine, abnormal urinalysis and MPO-ANCA titer all gradually ameliorated. The presence of extra-glomerular vasculitis, which was probably induced by ANCA, suggested that MPO-ANCA was an exacerbating factor for her prolonged renal dysfunction. This condition has so far only rarely been addressed in ANCA-positive IgA nephropathy.
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spelling pubmed-67020162019-08-21 A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria Yasukawa, Minoru Kitagawa, Sachiko Togashi, Ryo Asakawa, Shinichiro Nagura, Michito Arai, Shigeyuki Yamazaki, Osamu Tamura, Yoshifuru Kondo, Fukuo Ohashi, Ryuji Uchida, Shunya Shibata, Shigeru Fujigaki, Yoshihide Intern Med Case Report A 21-year-old woman presented with renal dysfunction during macrohematuria. A kidney biopsy revealed IgA nephropathy with a small percentage of crescent formation and macrohematuria-associated tubular injury. Macrohematuria-associated acute kidney injury could explain her renal dysfunction. However, she was seropositive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) and showed fibrin deposition around one arteriole. Corticosteroids and mycophenolate mofetil were administered as for ANCA vasculitis, and the serum creatinine, abnormal urinalysis and MPO-ANCA titer all gradually ameliorated. The presence of extra-glomerular vasculitis, which was probably induced by ANCA, suggested that MPO-ANCA was an exacerbating factor for her prolonged renal dysfunction. This condition has so far only rarely been addressed in ANCA-positive IgA nephropathy. The Japanese Society of Internal Medicine 2019-03-28 2019-07-15 /pmc/articles/PMC6702016/ /pubmed/30918194 http://dx.doi.org/10.2169/internalmedicine.2475-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yasukawa, Minoru
Kitagawa, Sachiko
Togashi, Ryo
Asakawa, Shinichiro
Nagura, Michito
Arai, Shigeyuki
Yamazaki, Osamu
Tamura, Yoshifuru
Kondo, Fukuo
Ohashi, Ryuji
Uchida, Shunya
Shibata, Shigeru
Fujigaki, Yoshihide
A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title_full A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title_fullStr A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title_full_unstemmed A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title_short A Patient with MPO-ANCA-positive IgA Nephropathy Diagnosed with the Clinical Onset of Macrohematuria
title_sort patient with mpo-anca-positive iga nephropathy diagnosed with the clinical onset of macrohematuria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702016/
https://www.ncbi.nlm.nih.gov/pubmed/30918194
http://dx.doi.org/10.2169/internalmedicine.2475-18
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