PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncogene in Renal Cell Carcinoma (RCC) cells. Validation of large-scale functional genomic scree...

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Detalles Bibliográficos
Autores principales: Bleu, Melusine, Gaulis, Swann, Lopes, Rui, Sprouffske, Kathleen, Apfel, Verena, Holwerda, Sjoerd, Pregnolato, Marco, Yildiz, Umut, Cordoʹ, Valentina, Dost, Antonella F. M., Knehr, Judith, Carbone, Walter, Lohmann, Felix, Lin, Charles Y., Bradner, James E., Kauffmann, Audrey, Tordella, Luca, Roma, Guglielmo, Galli, Giorgio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702156/
https://www.ncbi.nlm.nih.gov/pubmed/31431624
http://dx.doi.org/10.1038/s41467-019-11672-1

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