S1P(2) contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

Sphingosine 1-phosphate (S1P) signaling has emerged as a drug target in cerebral ischemia. Among S1P receptors, S1P(2) was recently identified to mediate ischemic brain injury. But, pathogenic mechanisms are not fully identified, particularly in view of microglial activation, a core pathogenesis in...

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Detalles Bibliográficos
Autores principales: Sapkota, Arjun, Gaire, Bhakta Prasad, Kang, Min-Gu, Choi, Ji Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702157/
https://www.ncbi.nlm.nih.gov/pubmed/31431671
http://dx.doi.org/10.1038/s41598-019-48609-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702157/
https://www.ncbi.nlm.nih.gov/pubmed/31431671
http://dx.doi.org/10.1038/s41598-019-48609-z

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