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S1P(2) contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK
Sphingosine 1-phosphate (S1P) signaling has emerged as a drug target in cerebral ischemia. Among S1P receptors, S1P(2) was recently identified to mediate ischemic brain injury. But, pathogenic mechanisms are not fully identified, particularly in view of microglial activation, a core pathogenesis in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702157/ https://www.ncbi.nlm.nih.gov/pubmed/31431671 http://dx.doi.org/10.1038/s41598-019-48609-z |