The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β isoform characterize prostate cancers with immune cell infiltration, particularly T cells and CD163+ macrophages. These can...

Descripción completa

Detalles Bibliográficos
Autores principales: Kazantseva, Marina, Mehta, Sunali, Eiholzer, Ramona A., Gimenez, Gregory, Bowie, Sara, Campbell, Hamish, Reily-Bell, Ashley L., Roth, Imogen, Ray, Sankalita, Drummond, Catherine J., Reid, Glen, Joruiz, Sebastien M., Wiles, Anna, Morrin, Helen R., Reader, Karen L., Hung, Noelyn A., Baird, Margaret A., Slatter, Tania L., Braithwaite, Antony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702175/
https://www.ncbi.nlm.nih.gov/pubmed/31431617
http://dx.doi.org/10.1038/s41419-019-1861-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702175/
https://www.ncbi.nlm.nih.gov/pubmed/31431617
http://dx.doi.org/10.1038/s41419-019-1861-1

Ejemplares similares