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Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways

BACKGROUND: This study assessed the clinical value of regional ischemic preconditioning (RIP) and the role of the mitogen-activated protein kinase (MAPK) pathways in the protective mechanism of RIP in cirrhotic hepatocellular carcinoma (HCC) patients undergoing hepatectomy. METHODS: Liver resection...

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Autores principales: Wang, Liming, Feng, Li, Rong, Weiqi, Liu, Mei, Wu, Fan, Yu, Weibo, An, Songlin, Zhou, Xiang, Wu, Jianxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702190/
https://www.ncbi.nlm.nih.gov/pubmed/30542823
http://dx.doi.org/10.1007/s11605-018-3960-1
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author Wang, Liming
Feng, Li
Rong, Weiqi
Liu, Mei
Wu, Fan
Yu, Weibo
An, Songlin
Zhou, Xiang
Wu, Jianxiong
author_facet Wang, Liming
Feng, Li
Rong, Weiqi
Liu, Mei
Wu, Fan
Yu, Weibo
An, Songlin
Zhou, Xiang
Wu, Jianxiong
author_sort Wang, Liming
collection PubMed
description BACKGROUND: This study assessed the clinical value of regional ischemic preconditioning (RIP) and the role of the mitogen-activated protein kinase (MAPK) pathways in the protective mechanism of RIP in cirrhotic hepatocellular carcinoma (HCC) patients undergoing hepatectomy. METHODS: Liver resection was performed with hemi-hepatic vascular inflow occlusion (HHV) under RIP (RIP group) or with HHV alone (HHV group). Clinical data, surgical outcomes, and the levels of phosphorylated MAPKs before occlusion and 30 min after reperfusion were estimated. RESULTS: HHV under RIP was associated with less intraoperative blood loss (300 vs. 400 ml; P = 0.042), postoperative plasma transfused (400 vs. 800 ml; P = 0.019), and a higher level of prothrombin activity at postoperative days 3, 5, and 7 compared to HHV alone. The level of phosphorylated ERK protein was significantly increased and the levels of phosphorylated p38 and JNK proteins were significantly decreased 30 min after reperfusion compared to HHV group in the RIP group. CONCLUSIONS: HHV under RIP may have clinical value in cirrhotic HCC patients requiring resection and the protective mechanism of RIP may be associated with changes in the protein phosphorylation level of MAPK pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11605-018-3960-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-67021902019-09-02 Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways Wang, Liming Feng, Li Rong, Weiqi Liu, Mei Wu, Fan Yu, Weibo An, Songlin Zhou, Xiang Wu, Jianxiong J Gastrointest Surg Original Article BACKGROUND: This study assessed the clinical value of regional ischemic preconditioning (RIP) and the role of the mitogen-activated protein kinase (MAPK) pathways in the protective mechanism of RIP in cirrhotic hepatocellular carcinoma (HCC) patients undergoing hepatectomy. METHODS: Liver resection was performed with hemi-hepatic vascular inflow occlusion (HHV) under RIP (RIP group) or with HHV alone (HHV group). Clinical data, surgical outcomes, and the levels of phosphorylated MAPKs before occlusion and 30 min after reperfusion were estimated. RESULTS: HHV under RIP was associated with less intraoperative blood loss (300 vs. 400 ml; P = 0.042), postoperative plasma transfused (400 vs. 800 ml; P = 0.019), and a higher level of prothrombin activity at postoperative days 3, 5, and 7 compared to HHV alone. The level of phosphorylated ERK protein was significantly increased and the levels of phosphorylated p38 and JNK proteins were significantly decreased 30 min after reperfusion compared to HHV group in the RIP group. CONCLUSIONS: HHV under RIP may have clinical value in cirrhotic HCC patients requiring resection and the protective mechanism of RIP may be associated with changes in the protein phosphorylation level of MAPK pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11605-018-3960-1) contains supplementary material, which is available to authorized users. Springer US 2018-12-12 2019 /pmc/articles/PMC6702190/ /pubmed/30542823 http://dx.doi.org/10.1007/s11605-018-3960-1 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Wang, Liming
Feng, Li
Rong, Weiqi
Liu, Mei
Wu, Fan
Yu, Weibo
An, Songlin
Zhou, Xiang
Wu, Jianxiong
Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title_full Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title_fullStr Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title_full_unstemmed Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title_short Regional Ischemic Preconditioning Has Clinical Value in Cirrhotic HCC Through MAPK Pathways
title_sort regional ischemic preconditioning has clinical value in cirrhotic hcc through mapk pathways
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702190/
https://www.ncbi.nlm.nih.gov/pubmed/30542823
http://dx.doi.org/10.1007/s11605-018-3960-1
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