Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze...

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Autores principales: Li, Geng, Pan, Pan, He, Qiuyan, Kong, Xiujuan, Wu, Kailang, Zhang, Wei, Liu, Yuntao, Huang, Huiting, Liu, Jianbo, Zhang, Zhongde, Wu, De, Lai, Xiaoping, Liu, Xiaohong, Wu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702253/
https://www.ncbi.nlm.nih.gov/pubmed/28120220
http://dx.doi.org/10.1007/s12250-016-3872-8
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author Li, Geng
Pan, Pan
He, Qiuyan
Kong, Xiujuan
Wu, Kailang
Zhang, Wei
Liu, Yuntao
Huang, Huiting
Liu, Jianbo
Zhang, Zhongde
Wu, De
Lai, Xiaoping
Liu, Xiaohong
Wu, Jianguo
author_facet Li, Geng
Pan, Pan
He, Qiuyan
Kong, Xiujuan
Wu, Kailang
Zhang, Wei
Liu, Yuntao
Huang, Huiting
Liu, Jianbo
Zhang, Zhongde
Wu, De
Lai, Xiaoping
Liu, Xiaohong
Wu, Jianguo
author_sort Li, Geng
collection PubMed
description The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. [Image: see text]
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spelling pubmed-67022532019-08-21 Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China Li, Geng Pan, Pan He, Qiuyan Kong, Xiujuan Wu, Kailang Zhang, Wei Liu, Yuntao Huang, Huiting Liu, Jianbo Zhang, Zhongde Wu, De Lai, Xiaoping Liu, Xiaohong Wu, Jianguo Virol Sin Research Article The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. [Image: see text] Springer Singapore 2017-01-23 /pmc/articles/PMC6702253/ /pubmed/28120220 http://dx.doi.org/10.1007/s12250-016-3872-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Li, Geng
Pan, Pan
He, Qiuyan
Kong, Xiujuan
Wu, Kailang
Zhang, Wei
Liu, Yuntao
Huang, Huiting
Liu, Jianbo
Zhang, Zhongde
Wu, De
Lai, Xiaoping
Liu, Xiaohong
Wu, Jianguo
Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title_full Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title_fullStr Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title_full_unstemmed Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title_short Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China
title_sort molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in guangzhou, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702253/
https://www.ncbi.nlm.nih.gov/pubmed/28120220
http://dx.doi.org/10.1007/s12250-016-3872-8
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