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In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica

Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patt...

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Autores principales: Sartoretti, Thomas, Mannil, Manoj, Biendl, Stefan, Froehlich, Johannes M., Alkadhi, Hatem, Zadory, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702290/
https://www.ncbi.nlm.nih.gov/pubmed/31432300
http://dx.doi.org/10.1186/s41747-019-0113-6
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author Sartoretti, Thomas
Mannil, Manoj
Biendl, Stefan
Froehlich, Johannes M.
Alkadhi, Hatem
Zadory, Matthias
author_facet Sartoretti, Thomas
Mannil, Manoj
Biendl, Stefan
Froehlich, Johannes M.
Alkadhi, Hatem
Zadory, Matthias
author_sort Sartoretti, Thomas
collection PubMed
description Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume.
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spelling pubmed-67022902019-09-02 In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica Sartoretti, Thomas Mannil, Manoj Biendl, Stefan Froehlich, Johannes M. Alkadhi, Hatem Zadory, Matthias Eur Radiol Exp Technical Note Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume. Springer International Publishing 2019-08-21 /pmc/articles/PMC6702290/ /pubmed/31432300 http://dx.doi.org/10.1186/s41747-019-0113-6 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Technical Note
Sartoretti, Thomas
Mannil, Manoj
Biendl, Stefan
Froehlich, Johannes M.
Alkadhi, Hatem
Zadory, Matthias
In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title_full In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title_fullStr In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title_full_unstemmed In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title_short In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
title_sort in vitro qualitative and quantitative ct assessment of iodinated aerosol nasal deposition using a 3d-printed nasal replica
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702290/
https://www.ncbi.nlm.nih.gov/pubmed/31432300
http://dx.doi.org/10.1186/s41747-019-0113-6
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