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In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica
Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patt...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702290/ https://www.ncbi.nlm.nih.gov/pubmed/31432300 http://dx.doi.org/10.1186/s41747-019-0113-6 |
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author | Sartoretti, Thomas Mannil, Manoj Biendl, Stefan Froehlich, Johannes M. Alkadhi, Hatem Zadory, Matthias |
author_facet | Sartoretti, Thomas Mannil, Manoj Biendl, Stefan Froehlich, Johannes M. Alkadhi, Hatem Zadory, Matthias |
author_sort | Sartoretti, Thomas |
collection | PubMed |
description | Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume. |
format | Online Article Text |
id | pubmed-6702290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-67022902019-09-02 In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica Sartoretti, Thomas Mannil, Manoj Biendl, Stefan Froehlich, Johannes M. Alkadhi, Hatem Zadory, Matthias Eur Radiol Exp Technical Note Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume. Springer International Publishing 2019-08-21 /pmc/articles/PMC6702290/ /pubmed/31432300 http://dx.doi.org/10.1186/s41747-019-0113-6 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Technical Note Sartoretti, Thomas Mannil, Manoj Biendl, Stefan Froehlich, Johannes M. Alkadhi, Hatem Zadory, Matthias In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title | In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title_full | In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title_fullStr | In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title_full_unstemmed | In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title_short | In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica |
title_sort | in vitro qualitative and quantitative ct assessment of iodinated aerosol nasal deposition using a 3d-printed nasal replica |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702290/ https://www.ncbi.nlm.nih.gov/pubmed/31432300 http://dx.doi.org/10.1186/s41747-019-0113-6 |
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