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Pre-plaque Aß-Mediated Impairment of Synaptic Depotentiation in a Transgenic Rat Model of Alzheimer’s Disease Amyloidosis

How endogenously produced soluble amyloid ß-protein (Aß) affects synaptic plasticity in vulnerable circuits should provide insight into early Alzheimer’s disease pathophysiology. McGill-R-Thy1-APP transgenic rats, modeling Alzheimer’s disease amyloidosis, exhibit an age-dependent soluble Aß-mediated...

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Detalles Bibliográficos
Autores principales:	Qi, Yingjie, Klyubin, Igor, Hu, Neng-Wei, Ondrejcak, Tomas, Rowan, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702302/ https://www.ncbi.nlm.nih.gov/pubmed/31474823 http://dx.doi.org/10.3389/fnins.2019.00861

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