Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous ch...

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Autores principales: Cai, Yuexin, Li, Jiahong, Chen, Yanhong, Chen, Wan, Dang, Caiping, Zhao, Fei, Li, Wenrui, Chen, Guisheng, Chen, Suijun, Liang, Maojin, Zheng, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702325/
https://www.ncbi.nlm.nih.gov/pubmed/31474821
http://dx.doi.org/10.3389/fnins.2019.00851
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author Cai, Yuexin
Li, Jiahong
Chen, Yanhong
Chen, Wan
Dang, Caiping
Zhao, Fei
Li, Wenrui
Chen, Guisheng
Chen, Suijun
Liang, Maojin
Zheng, Yiqing
author_facet Cai, Yuexin
Li, Jiahong
Chen, Yanhong
Chen, Wan
Dang, Caiping
Zhao, Fei
Li, Wenrui
Chen, Guisheng
Chen, Suijun
Liang, Maojin
Zheng, Yiqing
author_sort Cai, Yuexin
collection PubMed
description This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.
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spelling pubmed-67023252019-08-30 Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG Cai, Yuexin Li, Jiahong Chen, Yanhong Chen, Wan Dang, Caiping Zhao, Fei Li, Wenrui Chen, Guisheng Chen, Suijun Liang, Maojin Zheng, Yiqing Front Neurosci Neuroscience This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients. Frontiers Media S.A. 2019-08-14 /pmc/articles/PMC6702325/ /pubmed/31474821 http://dx.doi.org/10.3389/fnins.2019.00851 Text en Copyright © 2019 Cai, Li, Chen, Chen, Dang, Zhao, Li, Chen, Chen, Liang and Zheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cai, Yuexin
Li, Jiahong
Chen, Yanhong
Chen, Wan
Dang, Caiping
Zhao, Fei
Li, Wenrui
Chen, Guisheng
Chen, Suijun
Liang, Maojin
Zheng, Yiqing
Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title_full Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title_fullStr Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title_full_unstemmed Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title_short Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
title_sort inhibition of brain area and functional connectivity in idiopathic sudden sensorineural hearing loss with tinnitus, based on resting-state eeg
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702325/
https://www.ncbi.nlm.nih.gov/pubmed/31474821
http://dx.doi.org/10.3389/fnins.2019.00851
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