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Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat

The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. T...

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Autores principales: Chen, Xin-Yue, Gou, San-Hu, Shi, Zhi-Qiang, Xue, Zhi-Yuan, Feng, Shi-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702403/
https://www.ncbi.nlm.nih.gov/pubmed/31452965
http://dx.doi.org/10.1016/j.jpha.2018.10.004
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author Chen, Xin-Yue
Gou, San-Hu
Shi, Zhi-Qiang
Xue, Zhi-Yuan
Feng, Shi-Lan
author_facet Chen, Xin-Yue
Gou, San-Hu
Shi, Zhi-Qiang
Xue, Zhi-Yuan
Feng, Shi-Lan
author_sort Chen, Xin-Yue
collection PubMed
description The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value.
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spelling pubmed-67024032019-08-26 Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat Chen, Xin-Yue Gou, San-Hu Shi, Zhi-Qiang Xue, Zhi-Yuan Feng, Shi-Lan J Pharm Anal Original Article The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value. Xi'an Jiaotong University 2019-08 2018-11-01 /pmc/articles/PMC6702403/ /pubmed/31452965 http://dx.doi.org/10.1016/j.jpha.2018.10.004 Text en © 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Chen, Xin-Yue
Gou, San-Hu
Shi, Zhi-Qiang
Xue, Zhi-Yuan
Feng, Shi-Lan
Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title_full Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title_fullStr Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title_full_unstemmed Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title_short Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat
title_sort spectrum-effect relationship between hplc fingerprints and bioactive components of radix hedysari on increasing the peak bone mass of rat
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702403/
https://www.ncbi.nlm.nih.gov/pubmed/31452965
http://dx.doi.org/10.1016/j.jpha.2018.10.004
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