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Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702426/ https://www.ncbi.nlm.nih.gov/pubmed/31453397 http://dx.doi.org/10.1016/j.heliyon.2019.e02228 |
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author | El-Badry, Ayman A. El Sayed, Samar S. Hussein, Rafiaa R. Said, Youssef M. Al-Antably, Abeer S. Hassan, Marwa A. |
author_facet | El-Badry, Ayman A. El Sayed, Samar S. Hussein, Rafiaa R. Said, Youssef M. Al-Antably, Abeer S. Hassan, Marwa A. |
author_sort | El-Badry, Ayman A. |
collection | PubMed |
description | BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites in children with malignancies and those on chemotherapy. PROCEDURE: Stool samples were collected from 137 Egyptian hospitalized cancerous children with different malignancies in the National Cancer Institute, and receiving chemotherapy. Faecal samples were examined microscopically. Genomic copro-DNA was extracted from fecal samples and amplified by 3 separate nPCR assays targeting Cryptosporidium, G. intestinalis and Entamoeba histolytica complex. RESULT: The overall prevalence of enteroparasites was 6.6 % (9 cases). Only Giardia copro-DNA was encountered in 2 (1.4%) faecal samples of patients. Coproscopy detected parasites in 7 cases: Blastocystis spp. in 5 cases (3.6%), Hymenolepis nana in 1 case (0.7%) and Ascaris lumbericoides in 1 case (0.7%). CONCLUSION: Low prevalence may be due to patient's use of prophylactic anti-parasitic and anti-fungal drugs, a standard protocol, basic hygienic practices and good nursing all of which are preventive against enteroparasites transmission. Among studied variables only diarrhoeic individuals who had a solid tumor, and soft/liquid stool with mucus and blood were predictors of intestinal parasitism. |
format | Online Article Text |
id | pubmed-6702426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-67024262019-08-26 Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence El-Badry, Ayman A. El Sayed, Samar S. Hussein, Rafiaa R. Said, Youssef M. Al-Antably, Abeer S. Hassan, Marwa A. Heliyon Article BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites in children with malignancies and those on chemotherapy. PROCEDURE: Stool samples were collected from 137 Egyptian hospitalized cancerous children with different malignancies in the National Cancer Institute, and receiving chemotherapy. Faecal samples were examined microscopically. Genomic copro-DNA was extracted from fecal samples and amplified by 3 separate nPCR assays targeting Cryptosporidium, G. intestinalis and Entamoeba histolytica complex. RESULT: The overall prevalence of enteroparasites was 6.6 % (9 cases). Only Giardia copro-DNA was encountered in 2 (1.4%) faecal samples of patients. Coproscopy detected parasites in 7 cases: Blastocystis spp. in 5 cases (3.6%), Hymenolepis nana in 1 case (0.7%) and Ascaris lumbericoides in 1 case (0.7%). CONCLUSION: Low prevalence may be due to patient's use of prophylactic anti-parasitic and anti-fungal drugs, a standard protocol, basic hygienic practices and good nursing all of which are preventive against enteroparasites transmission. Among studied variables only diarrhoeic individuals who had a solid tumor, and soft/liquid stool with mucus and blood were predictors of intestinal parasitism. Elsevier 2019-08-12 /pmc/articles/PMC6702426/ /pubmed/31453397 http://dx.doi.org/10.1016/j.heliyon.2019.e02228 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article El-Badry, Ayman A. El Sayed, Samar S. Hussein, Rafiaa R. Said, Youssef M. Al-Antably, Abeer S. Hassan, Marwa A. Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title | Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title_full | Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title_fullStr | Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title_full_unstemmed | Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title_short | Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
title_sort | intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702426/ https://www.ncbi.nlm.nih.gov/pubmed/31453397 http://dx.doi.org/10.1016/j.heliyon.2019.e02228 |
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