Cargando…

Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence

BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Badry, Ayman A., El Sayed, Samar S., Hussein, Rafiaa R., Said, Youssef M., Al-Antably, Abeer S., Hassan, Marwa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702426/
https://www.ncbi.nlm.nih.gov/pubmed/31453397
http://dx.doi.org/10.1016/j.heliyon.2019.e02228
_version_ 1783445225554837504
author El-Badry, Ayman A.
El Sayed, Samar S.
Hussein, Rafiaa R.
Said, Youssef M.
Al-Antably, Abeer S.
Hassan, Marwa A.
author_facet El-Badry, Ayman A.
El Sayed, Samar S.
Hussein, Rafiaa R.
Said, Youssef M.
Al-Antably, Abeer S.
Hassan, Marwa A.
author_sort El-Badry, Ayman A.
collection PubMed
description BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites in children with malignancies and those on chemotherapy. PROCEDURE: Stool samples were collected from 137 Egyptian hospitalized cancerous children with different malignancies in the National Cancer Institute, and receiving chemotherapy. Faecal samples were examined microscopically. Genomic copro-DNA was extracted from fecal samples and amplified by 3 separate nPCR assays targeting Cryptosporidium, G. intestinalis and Entamoeba histolytica complex. RESULT: The overall prevalence of enteroparasites was 6.6 % (9 cases). Only Giardia copro-DNA was encountered in 2 (1.4%) faecal samples of patients. Coproscopy detected parasites in 7 cases: Blastocystis spp. in 5 cases (3.6%), Hymenolepis nana in 1 case (0.7%) and Ascaris lumbericoides in 1 case (0.7%). CONCLUSION: Low prevalence may be due to patient's use of prophylactic anti-parasitic and anti-fungal drugs, a standard protocol, basic hygienic practices and good nursing all of which are preventive against enteroparasites transmission. Among studied variables only diarrhoeic individuals who had a solid tumor, and soft/liquid stool with mucus and blood were predictors of intestinal parasitism.
format Online
Article
Text
id pubmed-6702426
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-67024262019-08-26 Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence El-Badry, Ayman A. El Sayed, Samar S. Hussein, Rafiaa R. Said, Youssef M. Al-Antably, Abeer S. Hassan, Marwa A. Heliyon Article BACKGROUND: Children with underlying malignancies and those on chemotherapy are at risk for having intestinal parasitic infections, which can lead to a severe course and death. This cross-sectional study was done to assess the copro-parasitological and copro-molecular prevalence of entero-parasites in children with malignancies and those on chemotherapy. PROCEDURE: Stool samples were collected from 137 Egyptian hospitalized cancerous children with different malignancies in the National Cancer Institute, and receiving chemotherapy. Faecal samples were examined microscopically. Genomic copro-DNA was extracted from fecal samples and amplified by 3 separate nPCR assays targeting Cryptosporidium, G. intestinalis and Entamoeba histolytica complex. RESULT: The overall prevalence of enteroparasites was 6.6 % (9 cases). Only Giardia copro-DNA was encountered in 2 (1.4%) faecal samples of patients. Coproscopy detected parasites in 7 cases: Blastocystis spp. in 5 cases (3.6%), Hymenolepis nana in 1 case (0.7%) and Ascaris lumbericoides in 1 case (0.7%). CONCLUSION: Low prevalence may be due to patient's use of prophylactic anti-parasitic and anti-fungal drugs, a standard protocol, basic hygienic practices and good nursing all of which are preventive against enteroparasites transmission. Among studied variables only diarrhoeic individuals who had a solid tumor, and soft/liquid stool with mucus and blood were predictors of intestinal parasitism. Elsevier 2019-08-12 /pmc/articles/PMC6702426/ /pubmed/31453397 http://dx.doi.org/10.1016/j.heliyon.2019.e02228 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
El-Badry, Ayman A.
El Sayed, Samar S.
Hussein, Rafiaa R.
Said, Youssef M.
Al-Antably, Abeer S.
Hassan, Marwa A.
Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title_full Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title_fullStr Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title_full_unstemmed Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title_short Intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
title_sort intestinal parasitism in pediatric oncology children receiving chemotherapy: unexpected low prevalence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702426/
https://www.ncbi.nlm.nih.gov/pubmed/31453397
http://dx.doi.org/10.1016/j.heliyon.2019.e02228
work_keys_str_mv AT elbadryaymana intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence
AT elsayedsamars intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence
AT husseinrafiaar intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence
AT saidyoussefm intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence
AT alantablyabeers intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence
AT hassanmarwaa intestinalparasitisminpediatriconcologychildrenreceivingchemotherapyunexpectedlowprevalence