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Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes

We identified autoantibodies (AAb) reacting with a variant IA-2 molecule (IA-2var) that has three amino acid substitutions (Cys(27), Gly(608), and Pro(671)) within the full-length molecule. We examined IA-2var AAb in first-degree relatives of type 1 diabetes (T1D) probands from the TrialNet Pathway...

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Detalles Bibliográficos
Autores principales:	Acevedo-Calado, Maria J., Pietropaolo, Susan L., Morran, Michael P., Schnell, Santiago, Vonberg, Andrew D., Verge, Charles F., Gianani, Roberto, Becker, Dorothy J., Huang, Shuai, Greenbaum, Carla J., Yu, Liping, Davidson, Howard W., Michels, Aaron W., Rich, Stephen S., Pietropaolo, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2019
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702638/ https://www.ncbi.nlm.nih.gov/pubmed/31167877 http://dx.doi.org/10.2337/db18-1351

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