Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report

Amyotrophic lateral sclerosis (ALS) is a disease of which the underlying etiology and pathogenesis are unknown. Numerous data indicate an important role of the immune system and mitochondrial function in the disease. Primary biliary cirrhosis (PBC) is an autoimmune liver disease resulting from a com...

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Autores principales: Zhang, Haibo, Liu, Yaling, Li, Zhenfei, Liang, Na, Zhou, Xiaomeng, Nie, Xiangyu, Zhang, Ting, Qi, Weijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702657/
https://www.ncbi.nlm.nih.gov/pubmed/31474934
http://dx.doi.org/10.3389/fneur.2019.00890
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author Zhang, Haibo
Liu, Yaling
Li, Zhenfei
Liang, Na
Zhou, Xiaomeng
Nie, Xiangyu
Zhang, Ting
Qi, Weijing
author_facet Zhang, Haibo
Liu, Yaling
Li, Zhenfei
Liang, Na
Zhou, Xiaomeng
Nie, Xiangyu
Zhang, Ting
Qi, Weijing
author_sort Zhang, Haibo
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a disease of which the underlying etiology and pathogenesis are unknown. Numerous data indicate an important role of the immune system and mitochondrial function in the disease. Primary biliary cirrhosis (PBC) is an autoimmune liver disease resulting from a combination of genetic and environmental risk factors. Patients with PBC develop innate and adaptive immune reactions against mitochondrial antigens. Therefore, common mechanisms could exist in both diseases. We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients.
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spelling pubmed-67026572019-08-30 Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report Zhang, Haibo Liu, Yaling Li, Zhenfei Liang, Na Zhou, Xiaomeng Nie, Xiangyu Zhang, Ting Qi, Weijing Front Neurol Neurology Amyotrophic lateral sclerosis (ALS) is a disease of which the underlying etiology and pathogenesis are unknown. Numerous data indicate an important role of the immune system and mitochondrial function in the disease. Primary biliary cirrhosis (PBC) is an autoimmune liver disease resulting from a combination of genetic and environmental risk factors. Patients with PBC develop innate and adaptive immune reactions against mitochondrial antigens. Therefore, common mechanisms could exist in both diseases. We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients. Frontiers Media S.A. 2019-08-14 /pmc/articles/PMC6702657/ /pubmed/31474934 http://dx.doi.org/10.3389/fneur.2019.00890 Text en Copyright © 2019 Zhang, Liu, Li, Liang, Zhou, Nie, Zhang and Qi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhang, Haibo
Liu, Yaling
Li, Zhenfei
Liang, Na
Zhou, Xiaomeng
Nie, Xiangyu
Zhang, Ting
Qi, Weijing
Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title_full Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title_fullStr Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title_full_unstemmed Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title_short Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report
title_sort amyotrophic lateral sclerosis and primary biliary cirrhosis overlap syndrome: two cases report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702657/
https://www.ncbi.nlm.nih.gov/pubmed/31474934
http://dx.doi.org/10.3389/fneur.2019.00890
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