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CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

BACKGROUND: Mast cell activation causes degranulation and release of cytokines, thereby promoting inflammation. The aim of this study was to investigate the inhibitory effect of CDK4/6 inhibition on mast cell activation in vitro and in vivo. METHODS: RBL-2H3 rat basophilic leukemia cells (BLCs) and...

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Detalles Bibliográficos
Autores principales:	Hou, Yi-Bo, Ji, Kunmei, Sun, Yue-Tong, Zhang, Li-Na, Chen, Jia-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702723/ https://www.ncbi.nlm.nih.gov/pubmed/31429774 http://dx.doi.org/10.1186/s12967-019-2026-9

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