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Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India

INTRODUCTION: The purpose of this study was to investigate the prevalence of Postoperative central nervous system infections (PCNSIs) and antibiotic resistance profiles of causative organisms in trauma patients following neuroinvasive procedures. MATERIALS AND METHODS: This was a retrospective study...

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Autores principales: Govindaswamy, Aishwarya, Bajpai, Vijeta, Singh, Parul, Lohiya, Ayush, Ayyanar, Muruganantham, Gupta, Deepak Kumar, Bindra, Ashish, Singh, Gyaninder Pal, Mathur, Purva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703012/
https://www.ncbi.nlm.nih.gov/pubmed/31497110
http://dx.doi.org/10.4103/ajns.AJNS_268_18
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author Govindaswamy, Aishwarya
Bajpai, Vijeta
Singh, Parul
Lohiya, Ayush
Ayyanar, Muruganantham
Gupta, Deepak Kumar
Bindra, Ashish
Singh, Gyaninder Pal
Mathur, Purva
author_facet Govindaswamy, Aishwarya
Bajpai, Vijeta
Singh, Parul
Lohiya, Ayush
Ayyanar, Muruganantham
Gupta, Deepak Kumar
Bindra, Ashish
Singh, Gyaninder Pal
Mathur, Purva
author_sort Govindaswamy, Aishwarya
collection PubMed
description INTRODUCTION: The purpose of this study was to investigate the prevalence of Postoperative central nervous system infections (PCNSIs) and antibiotic resistance profiles of causative organisms in trauma patients following neuroinvasive procedures. MATERIALS AND METHODS: This was a retrospective study conducted over a period of 4 years (2013–2017). All in-patients admitted under a neurotrauma unit meeting the inclusion criteria of PCNSIs were included in the study. Surgical site infections (SSIs) were defined according to the Centers for Disease Control and Prevention 2018 (CDC) criteria. We retrospectively examined the demographic characteristics, type of neurosurgery performed, laboratory data, causative organisms, and antimicrobial susceptibility testing results of patients who had positive cerebrospinal fluid cultures following craniotomy between January 2013 and December 2017. RESULTS: Of total 2500 patients operated during the study, 961 patients were screened for PCNSIs. The estimated prevalence (95% confidence interval) of PCNSIs which is a type of organ/space SSI was 7.2% (6.3–8.3). Males were predominantly affected (85.0%). The mean age (standard deviation) of patients was 31.9 (16.5) years. Of all the cultures sent for microbiological examination, 18.6% were positive. The proportion of Gram-negative bacteria causing PCNSIs was 91.6%. Multidrug-resistant (MDR) Acinetobacter baumannii (41%) was the most common organism isolated. Among Gram-positive bacteria, the most common organism was Staphylococcus aureus (5.5%). All the Gram-positive isolates were susceptible to vancomycin, teicoplanin, and linezolid. CONCLUSION: There is a high burden of PCNSI caused by MDR Acinetobacter baumannii can pose a major clinical challenge with only few antimicrobials left in the pipeline.
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spelling pubmed-67030122019-09-06 Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India Govindaswamy, Aishwarya Bajpai, Vijeta Singh, Parul Lohiya, Ayush Ayyanar, Muruganantham Gupta, Deepak Kumar Bindra, Ashish Singh, Gyaninder Pal Mathur, Purva Asian J Neurosurg Original Article INTRODUCTION: The purpose of this study was to investigate the prevalence of Postoperative central nervous system infections (PCNSIs) and antibiotic resistance profiles of causative organisms in trauma patients following neuroinvasive procedures. MATERIALS AND METHODS: This was a retrospective study conducted over a period of 4 years (2013–2017). All in-patients admitted under a neurotrauma unit meeting the inclusion criteria of PCNSIs were included in the study. Surgical site infections (SSIs) were defined according to the Centers for Disease Control and Prevention 2018 (CDC) criteria. We retrospectively examined the demographic characteristics, type of neurosurgery performed, laboratory data, causative organisms, and antimicrobial susceptibility testing results of patients who had positive cerebrospinal fluid cultures following craniotomy between January 2013 and December 2017. RESULTS: Of total 2500 patients operated during the study, 961 patients were screened for PCNSIs. The estimated prevalence (95% confidence interval) of PCNSIs which is a type of organ/space SSI was 7.2% (6.3–8.3). Males were predominantly affected (85.0%). The mean age (standard deviation) of patients was 31.9 (16.5) years. Of all the cultures sent for microbiological examination, 18.6% were positive. The proportion of Gram-negative bacteria causing PCNSIs was 91.6%. Multidrug-resistant (MDR) Acinetobacter baumannii (41%) was the most common organism isolated. Among Gram-positive bacteria, the most common organism was Staphylococcus aureus (5.5%). All the Gram-positive isolates were susceptible to vancomycin, teicoplanin, and linezolid. CONCLUSION: There is a high burden of PCNSI caused by MDR Acinetobacter baumannii can pose a major clinical challenge with only few antimicrobials left in the pipeline. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6703012/ /pubmed/31497110 http://dx.doi.org/10.4103/ajns.AJNS_268_18 Text en Copyright: © 2019 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Govindaswamy, Aishwarya
Bajpai, Vijeta
Singh, Parul
Lohiya, Ayush
Ayyanar, Muruganantham
Gupta, Deepak Kumar
Bindra, Ashish
Singh, Gyaninder Pal
Mathur, Purva
Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title_full Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title_fullStr Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title_full_unstemmed Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title_short Prevalence and Antibiotic Resistance Profile of Cerebrospinal Fluid Pathogens from Neurosurgical Patients from Level 1 Trauma Center in India
title_sort prevalence and antibiotic resistance profile of cerebrospinal fluid pathogens from neurosurgical patients from level 1 trauma center in india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703012/
https://www.ncbi.nlm.nih.gov/pubmed/31497110
http://dx.doi.org/10.4103/ajns.AJNS_268_18
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