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PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

Idiopathic pulmonary fibrosis (IPF) is a fatal ageing-related disease linked to mitochondrial dysfunction. The present study aimed to determine whether peroxisome proliferator activated receptor gamma co-activator 1-alpha (PPARGC1A, encoding PGC1α), a master regulator of mitochondrial biogenesis, is...

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Detalles Bibliográficos
Autores principales:	Caporarello, Nunzia, Meridew, Jeffrey A, Jones, Dakota L, Tan, Qi, Haak, Andrew J, Choi, Kyoung M, Manlove, Logan J, Prakash, Y S, Tschumperlin, Daniel J, Ligresti, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Interstitial Lung Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703129/ https://www.ncbi.nlm.nih.gov/pubmed/31182654 http://dx.doi.org/10.1136/thoraxjnl-2019-213064

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