cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

The Alzheimer’s disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin binding adaptor protein, but its function in the nervous system is largely unknown. Loss of the Drosophila ortholog cindr enhances neurotoxicity of human Tau, which forms neurofibrillary tangle patholo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ojelade, Shamsideen A., Lee, Tom V., Giagtzoglou, Nikolaos, Yu, Lei, Ugur, Berrak, Li, Yarong, Duraine, Lita, Zuo, Zhongyuan, Petyuk, Vlad, De Jager, Philip L., Bennett, David A., Arenkiel, Benjamin R., Bellen, Hugo J., Shulman, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703184/
https://www.ncbi.nlm.nih.gov/pubmed/31412248
http://dx.doi.org/10.1016/j.celrep.2019.07.041

Ejemplares similares

Ejemplares similares