Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34(+) Hematopoietic Progenitor Cells and Humanized NSG Mice

Human cytomegalovirus (HCMV) infection of CD34(+) hematopoietic progenitor cells (CD34(+) HPCs) provides a critical reservoir of virus in stem cell transplant patients, and viral reactivation remains a significant cause of morbidity and mortality. The HCMV chemokine receptor US28 is implicated in th...

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Detalles Bibliográficos
Autores principales: Crawford, Lindsey B., Caposio, Patrizia, Kreklywich, Craig, Pham, Andrew H., Hancock, Meaghan H., Jones, Taylor A., Smith, Patricia P., Yurochko, Andrew D., Nelson, Jay A., Streblow, Daniel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703429/
https://www.ncbi.nlm.nih.gov/pubmed/31431555
http://dx.doi.org/10.1128/mBio.01889-19

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