Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that ex...

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Detalles Bibliográficos
Autores principales: Butler, Victoria J., Gao, Fuying, Corrales, Christian I., Cortopassi, Wilian A., Caballero, Benjamin, Vohra, Mihir, Ashrafi, Kaveh, Cuervo, Ana Maria, Jacobson, Matthew P., Coppola, Giovanni, Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703691/
https://www.ncbi.nlm.nih.gov/pubmed/31398187
http://dx.doi.org/10.1371/journal.pgen.1008295

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