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A human subcortical network underlying social avoidance revealed by risky economic choices

Social interactions have a major impact on well-being. While many individuals actively seek social situations, others avoid them, at great cost to their private and professional life. The neural mechanisms underlying individual differences in social approach or avoidance tendencies are poorly unders...

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Detalles Bibliográficos
Autores principales: Schultz, Johannes, Willems, Tom, Gädeke, Maria, Chakkour, Ghada, Franke, Alexander, Weber, Bernd, Hurlemann, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703852/
https://www.ncbi.nlm.nih.gov/pubmed/31329098
http://dx.doi.org/10.7554/eLife.45249
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author Schultz, Johannes
Willems, Tom
Gädeke, Maria
Chakkour, Ghada
Franke, Alexander
Weber, Bernd
Hurlemann, Rene
author_facet Schultz, Johannes
Willems, Tom
Gädeke, Maria
Chakkour, Ghada
Franke, Alexander
Weber, Bernd
Hurlemann, Rene
author_sort Schultz, Johannes
collection PubMed
description Social interactions have a major impact on well-being. While many individuals actively seek social situations, others avoid them, at great cost to their private and professional life. The neural mechanisms underlying individual differences in social approach or avoidance tendencies are poorly understood. Here we estimated people’s subjective value of engaging in a social situation. In each trial, more or less socially anxious participants chose between an interaction with a human partner providing social feedback and a monetary amount. With increasing social anxiety, the subjective value of social engagement decreased; amygdala BOLD response during decision-making and when experiencing social feedback increased; ventral striatum BOLD response to positive social feedback decreased; and connectivity between these regions during decision-making increased. Amygdala response was negatively related to the subjective value of social engagement. These findings suggest a relation between trait social anxiety/social avoidance and activity in a subcortical network during social decision-making.
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spelling pubmed-67038522019-08-22 A human subcortical network underlying social avoidance revealed by risky economic choices Schultz, Johannes Willems, Tom Gädeke, Maria Chakkour, Ghada Franke, Alexander Weber, Bernd Hurlemann, Rene eLife Neuroscience Social interactions have a major impact on well-being. While many individuals actively seek social situations, others avoid them, at great cost to their private and professional life. The neural mechanisms underlying individual differences in social approach or avoidance tendencies are poorly understood. Here we estimated people’s subjective value of engaging in a social situation. In each trial, more or less socially anxious participants chose between an interaction with a human partner providing social feedback and a monetary amount. With increasing social anxiety, the subjective value of social engagement decreased; amygdala BOLD response during decision-making and when experiencing social feedback increased; ventral striatum BOLD response to positive social feedback decreased; and connectivity between these regions during decision-making increased. Amygdala response was negatively related to the subjective value of social engagement. These findings suggest a relation between trait social anxiety/social avoidance and activity in a subcortical network during social decision-making. eLife Sciences Publications, Ltd 2019-07-22 /pmc/articles/PMC6703852/ /pubmed/31329098 http://dx.doi.org/10.7554/eLife.45249 Text en © 2019, Schultz et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Schultz, Johannes
Willems, Tom
Gädeke, Maria
Chakkour, Ghada
Franke, Alexander
Weber, Bernd
Hurlemann, Rene
A human subcortical network underlying social avoidance revealed by risky economic choices
title A human subcortical network underlying social avoidance revealed by risky economic choices
title_full A human subcortical network underlying social avoidance revealed by risky economic choices
title_fullStr A human subcortical network underlying social avoidance revealed by risky economic choices
title_full_unstemmed A human subcortical network underlying social avoidance revealed by risky economic choices
title_short A human subcortical network underlying social avoidance revealed by risky economic choices
title_sort human subcortical network underlying social avoidance revealed by risky economic choices
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703852/
https://www.ncbi.nlm.nih.gov/pubmed/31329098
http://dx.doi.org/10.7554/eLife.45249
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