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Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies

Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics un...

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Detalles Bibliográficos
Autores principales:	Lu, Lu, Li, Zhen, Li, He, Li, Xuejin, Vekilov, Peter G., Karniadakis, George Em
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703859/ https://www.ncbi.nlm.nih.gov/pubmed/31457104 http://dx.doi.org/10.1126/sciadv.aax3905

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